Document Detail

Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions.
MedLine Citation:
PMID:  19217918     Owner:  NLM     Status:  MEDLINE    
This study assessed the effects of the opioid antagonist naltrexone, the dopamine 2-like (D2) antagonist raclopride, and the GABA(B) agonist baclofen on consumption of fat/sucrose mixtures (FSM) using a limited access protocol. Sixty male Sprague-Dawley rats were grouped according to two schedules of access (Daily [D] or Intermittent [I]) to an optional FSM. Each FSM was created by whipping 3.2% (L), 10% (M), or 32% (H) powdered sugar into 100% vegetable shortening in a w/w manner (n=10 per group). One-hour intakes of the IL and IM groups were significantly greater than intakes of the respective DL and DM groups, thus fulfilling our operational definition of binge-type eating in these groups. Baclofen reduced intakes of the L and M mixtures regardless of access schedule, but failed to reduce intake of the H mixture. Naltrexone reduced intake in all groups, but potency was greater in IL rats than in DL rats. Furthermore, potency was attenuated in Intermittent rats, but enhanced in Daily rats, at higher sucrose concentrations. Raclopride reduced intake in the DL and stimulated intake in the IL groups, reduced intake in both M groups, and was without effect in both H groups. These results indicate that fat/sucrose mixtures containing relatively low concentrations of sucrose allow distinctions to be made between: 1) intakes stimulated by different access schedules and 2) opioid and dopaminergic modulation of those intakes. These results also suggest that brief bouts of food consumption involving fatty, sugar-rich foods may prove to be particularly resistant to pharmacological intervention.
K J Wong; F H W Wojnicki; R L W Corwin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-02-13
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  92     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-08-05     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-36     Citation Subset:  IM    
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MeSH Terms
Baclofen / pharmacology*
Dietary Fats / administration & dosage*
Dietary Sucrose / administration & dosage*
Dopamine Antagonists / pharmacology
Feeding Behavior / drug effects
GABA Agonists / pharmacology
Naltrexone / pharmacology*
Raclopride / pharmacology*
Rats, Sprague-Dawley
Grant Support
1-R01-MH67943/MH/NIMH NIH HHS; R01 MH067943/MH/NIMH NIH HHS; R01 MH067943-04/MH/NIMH NIH HHS
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Sucrose; 0/Dopamine Antagonists; 0/GABA Agonists; 430K3SOZ7G/Raclopride; 5S6W795CQM/Naltrexone; H789N3FKE8/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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