| Baclofen prevents the increase of myocardial oxygen demand indexes evoked by the hypothalamic stimulation in rabbits. | |
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MedLine Citation:
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PMID: 7901774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The electrical stimulation of the paraventricular nucleus (PVN) of the hypothalamus in anaesthetized rabbits elicited important cardiovascular responses which were mainly characterized by increases in arterial pressure, dP/dtmax, and of the indexes of myocardial oxygen consumption, rate-pressure product (from 34 +/- 2 to 40 +/- 2 mmHg.bpm.10(-3) and triple product (from 102 +/- 12 to 162 +/- 19 mmHg2.s-1.bpm.10(-6). The hemodynamic alterations induced by PVN stimulation were similar to those observed during physical effort and stressful situations. Intracerebroventricular (0.1, 0.3 and 1 microgram.kg-1) or intravenous administration (1, 3 and 10 mg.kg-1) of baclofen, a selective GABAB receptor agonist, induced a dose-related decrease in the peak values of dP/dtmax and of the indexes of myocardial oxygen consumption (rate-pressure and triple products) during the electrical PVN stimulation. After 1 microgram.kg-1 baclofen (i.c.v.), the peak value of the triple product during PVN stimulation was 101 +/- 21 as compared to 149 +/- 15 before treatment. At the 10 mg.kg-1 dose (i.v.), the triple product during stimulation only reached 90 +/- 20 vs. 150 +/- 20 before treatment. These results suggested that a type B GABAergic transmission system is involved in the modulation of central control of the cardiac function. Drugs modulating this system could therefore be designed to blunt the myocardial oxygen demand increases. |
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Authors:
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E Tibirica; L Monassier; J Feldman; C Brandt; A Verdun; P Bousquet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 348 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-06 Completed Date: 1993-12-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 164-71 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacologie Cardiovasculaire et Rénale, CNRS URA 589, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Baclofen / pharmacology* Dose-Response Relationship, Drug Electric Stimulation Glutamates / pharmacology Glutamic Acid Hemodynamics / drug effects Injections, Intravenous Injections, Intraventricular Kainic Acid / pharmacology Male Myocardial Contraction / drug effects Myocardium / metabolism* Oxygen Consumption / drug effects* Paraventricular Hypothalamic Nucleus / physiology* Rabbits Receptors, GABA / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Receptors, GABA; 1134-47-0/Baclofen; 487-79-6/Kainic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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