Document Detail


Baclofen: intestinal absorption mechanism in mice.
MedLine Citation:
PMID:  8981079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The duodenal transfer of baclofen from sacs of mouse intestine was determined. 2. A linear relationship between the steady-state transfer rate of total and the initial mucosal baclofen concentration was observed, suggesting that the clearance is the same at different concentrations. 3. There was no significant difference in the amount of total drug removed between control and everted tissues. 4. The data support the idea that the principal transfer mechanism for baclofen is simple diffusion in mouse intestine.
Authors:
G N Balerio; M C Rubio
Related Documents :
23829159 - Rating of perceived exertion after 12 weeks of high-intensity, intermittent sprinting.
12671319 - Effects of exercise following lateral fluid percussion brain injury in rats.
24816889 - Autonomic modulation in resistance-trained individuals after acute resistance exercise.
11466439 - Circulating insulin-like growth factor i mediates the protective effects of physical ex...
23814719 - Assessment of the effects of pranayama/alternate nostril breathing on the parasympathet...
23795769 - Exercise holds immediate benefits for affect and cognition in younger and older adults.
17669559 - Anthropometric measurements of mid-upper arm as a mortality predictor for community-dwe...
16137509 - Changes in qrs duration are associated with maximal exercise capacity in adult patients...
2009799 - Increased airways responsiveness in swine farmers.
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  27     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1269-71     Citation Subset:  IM    
Affiliation:
Catedra de Farmacología, Fácultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Baclofen / analysis,  pharmacokinetics*
Chemistry, Physical
Chromatography, High Pressure Liquid
Diffusion
Duodenum / metabolism
Intestinal Absorption / physiology*
Intestinal Mucosa / metabolism
Male
Mice
Muscle Relaxants, Central / analysis,  pharmacokinetics*
Physicochemical Phenomena
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Muscle Relaxants, Central; 1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Some pharmacologic and toxicologic studies on Rhazya stricta decne in rats, mice and rabbits.
Next Document:  Are imidazoline receptors involved in sympathetic neurotransmission in rat vas deferens?