Document Detail

Baclofen: intestinal absorption mechanism in mice.
MedLine Citation:
PMID:  8981079     Owner:  NLM     Status:  MEDLINE    
1. The duodenal transfer of baclofen from sacs of mouse intestine was determined. 2. A linear relationship between the steady-state transfer rate of total and the initial mucosal baclofen concentration was observed, suggesting that the clearance is the same at different concentrations. 3. There was no significant difference in the amount of total drug removed between control and everted tissues. 4. The data support the idea that the principal transfer mechanism for baclofen is simple diffusion in mouse intestine.
G N Balerio; M C Rubio
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  27     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1269-71     Citation Subset:  IM    
Catedra de Farmacología, Fácultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
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MeSH Terms
Baclofen / analysis,  pharmacokinetics*
Chemistry, Physical
Chromatography, High Pressure Liquid
Duodenum / metabolism
Intestinal Absorption / physiology*
Intestinal Mucosa / metabolism
Muscle Relaxants, Central / analysis,  pharmacokinetics*
Physicochemical Phenomena
Spectrophotometry, Ultraviolet
Reg. No./Substance:
0/Muscle Relaxants, Central; 1134-47-0/Baclofen

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