Document Detail


Baclofen-induced psychosis.
MedLine Citation:
PMID:  17047139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report a case of psychosis induced by therapeutic doses of baclofen. CASE SUMMARY: A 32-year-old Hindu man was prescribed oral baclofen 10 mg twice daily for relief of muscular spasms secondary to tetanus. After 4 weeks of baclofen use, he presented to the psychiatry emergency facility with a 4 day history of third-person auditory hallucinations and persecutory and referential delusions without underlying mood symptoms. These symptoms resolved within 1 week of discontinuing baclofen. Rechallenge with baclofen resulted in reemergence of psychotic symptoms, which disappeared after discontinuing baclofen. DISCUSSION: Reemergence of psychotic symptoms after rechallenge with baclofen suggests baclofen-induced psychosis. Use of the Naranjo probability scale indicates a probable association of baclofen with this patient's psychosis. The absence of underlying mood disorder makes this case different from previously reported ones. CONCLUSIONS: Baclofen may be associated with the occurrence of psychosis. Clinicians should consider baclofen-induced psychosis as a differential diagnosis in patients presenting with psychosis during treatment with this drug.
Authors:
Jatinder Mohan Chawla; Rajesh Sagar
Related Documents :
16949249 - Selective mutism and anxiety: a review of the current conceptualization of the disorder.
22440599 - Persistent neurological deficit from iodinated contrast encephalopathy following intrac...
22558479 - Left-sided gastroschisis with placenta findings: case report and literature review.
9193969 - Icd-10 mild cognitive disorder: its outcome three years later.
23872119 - A two year study of verified spider bites in switzerland and a review of the european s...
23120709 - Palatal foreign body mimicking a neoplasm.
9480409 - Rat-bite fever--new mexico, 1996.
6401389 - Nonexudative diarrhea after gold salt therapy: case report and review of the literature.
8585829 - Agenesis and lipoma of corpus callosum. case report.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-10-17
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  40     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2071-3     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Baclofen / adverse effects*
Humans
Male
Psychoses, Substance-Induced / diagnosis*,  psychology
Chemical
Reg. No./Substance:
1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Peritoneal fluid penetration of tigecycline.
Next Document:  GI risk factors and use of GI protective agents among patients receiving nonsteroidal antiinflammato...