Document Detail

Baclofen-induced psychosis.
MedLine Citation:
PMID:  17047139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of psychosis induced by therapeutic doses of baclofen. CASE SUMMARY: A 32-year-old Hindu man was prescribed oral baclofen 10 mg twice daily for relief of muscular spasms secondary to tetanus. After 4 weeks of baclofen use, he presented to the psychiatry emergency facility with a 4 day history of third-person auditory hallucinations and persecutory and referential delusions without underlying mood symptoms. These symptoms resolved within 1 week of discontinuing baclofen. Rechallenge with baclofen resulted in reemergence of psychotic symptoms, which disappeared after discontinuing baclofen. DISCUSSION: Reemergence of psychotic symptoms after rechallenge with baclofen suggests baclofen-induced psychosis. Use of the Naranjo probability scale indicates a probable association of baclofen with this patient's psychosis. The absence of underlying mood disorder makes this case different from previously reported ones. CONCLUSIONS: Baclofen may be associated with the occurrence of psychosis. Clinicians should consider baclofen-induced psychosis as a differential diagnosis in patients presenting with psychosis during treatment with this drug.
Jatinder Mohan Chawla; Rajesh Sagar
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-10-17
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  40     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2071-3     Citation Subset:  IM    
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Baclofen / adverse effects*
Psychoses, Substance-Induced / diagnosis*,  psychology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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