| Baclofen-induced psychosis. | |
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MedLine Citation:
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PMID: 17047139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of psychosis induced by therapeutic doses of baclofen. CASE SUMMARY: A 32-year-old Hindu man was prescribed oral baclofen 10 mg twice daily for relief of muscular spasms secondary to tetanus. After 4 weeks of baclofen use, he presented to the psychiatry emergency facility with a 4 day history of third-person auditory hallucinations and persecutory and referential delusions without underlying mood symptoms. These symptoms resolved within 1 week of discontinuing baclofen. Rechallenge with baclofen resulted in reemergence of psychotic symptoms, which disappeared after discontinuing baclofen. DISCUSSION: Reemergence of psychotic symptoms after rechallenge with baclofen suggests baclofen-induced psychosis. Use of the Naranjo probability scale indicates a probable association of baclofen with this patient's psychosis. The absence of underlying mood disorder makes this case different from previously reported ones. CONCLUSIONS: Baclofen may be associated with the occurrence of psychosis. Clinicians should consider baclofen-induced psychosis as a differential diagnosis in patients presenting with psychosis during treatment with this drug. |
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Authors:
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Jatinder Mohan Chawla; Rajesh Sagar |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-10-17 |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 40 ISSN: 1542-6270 ISO Abbreviation: Ann Pharmacother Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-01 Completed Date: 2007-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 2071-3 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Baclofen / adverse effects* Humans Male Psychoses, Substance-Induced / diagnosis*, psychology |
| Chemical | |
Reg. No./Substance:
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1134-47-0/Baclofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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