Document Detail

Baclofen-induced antinociception and nicotinic receptor mechanism(s).
MedLine Citation:
PMID:  10608489     Owner:  NLM     Status:  MEDLINE    
In this study, the influences of nicotinic receptor agents on baclofen-induced antinociception in the tail-flick test have been studied. Intraperitoneal administration of baclofen (2.5, 5 and 10 mg/kg) to mice induced a dose-dependent antinociception in the tail-flick test. Subcutaneous injection of nicotine (0.5-2.5 mg/kg) also caused a dose-dependent antinociceptive response. Intracerebral (10 and 20 microg/mouse) but not intraperitoneal administration of hexamethonium (5 and 10 mg/kg) to mice decreased the response of both nicotine and baclofen. However, administration of the GABA(B) antagonist CGP 35348 (100 and 200 mg/kg) decreased the response induced by baclofen but not by nicotine. It is concluded that at least part of the baclofen-induced antinociception may be mediated through a nicotinic mechanism.
M Sabetkasai; S Ahang; B Shafaghi; M R Zarrindast
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  85     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, University of Shahid-Beheshti Medical Sciences, Tehran University of Medical Sciences, Iran.
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MeSH Terms
Analgesics / pharmacology*
Baclofen / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
GABA Antagonists / pharmacology
Hexamethonium / pharmacology*
Nicotine / administration & dosage,  pharmacology*
Organophosphorus Compounds / pharmacology*
Pain Measurement / methods*
Receptors, Nicotinic / physiology
Time Factors
Reg. No./Substance:
0/Analgesics; 0/GABA Antagonists; 0/Organophosphorus Compounds; 0/Receptors, Nicotinic; 1134-47-0/Baclofen; 123690-79-9/CGP 35348; 54-11-5/Nicotine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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