| Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. | |
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MedLine Citation:
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PMID: 6372646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia. Baclofen significantly decreased the number of painful paroxysms in 7 of the 10 patients. An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25). On long-term follow-up of one to five years (mean, 3.0 years), 18 of the 60 patients (30%) continued pain free while receiving baclofen; 10 (17%) went into remission after 3 to 6 months; 13 (22%) became refractory to baclofen after 1 to 18 months; and 2 (3%) elected operation despite a good response to baclofen. The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia. |
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Authors:
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G H Fromm; C F Terrence; A S Chattha |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Annals of neurology Volume: 15 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-06-11 Completed Date: 1984-06-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Baclofen / therapeutic use* Carbamazepine / therapeutic use Clinical Trials as Topic Double-Blind Method Drug Synergism Drug Therapy, Combination Female Follow-Up Studies Humans Male Middle Aged Phenytoin / therapeutic use Time Factors Trigeminal Neuralgia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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1134-47-0/Baclofen; 298-46-4/Carbamazepine; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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