Document Detail

Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up.
MedLine Citation:
PMID:  6372646     Owner:  NLM     Status:  MEDLINE    
A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia. Baclofen significantly decreased the number of painful paroxysms in 7 of the 10 patients. An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25). On long-term follow-up of one to five years (mean, 3.0 years), 18 of the 60 patients (30%) continued pain free while receiving baclofen; 10 (17%) went into remission after 3 to 6 months; 13 (22%) became refractory to baclofen after 1 to 18 months; and 2 (3%) elected operation despite a good response to baclofen. The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia.
G H Fromm; C F Terrence; A S Chattha
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  15     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-11     Completed Date:  1984-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM    
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MeSH Terms
Baclofen / therapeutic use*
Carbamazepine / therapeutic use
Clinical Trials as Topic
Double-Blind Method
Drug Synergism
Drug Therapy, Combination
Follow-Up Studies
Middle Aged
Phenytoin / therapeutic use
Time Factors
Trigeminal Neuralgia / drug therapy*
Reg. No./Substance:
1134-47-0/Baclofen; 298-46-4/Carbamazepine; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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