Document Detail

Baclofen-induced reductions in optional food intake depend upon food composition.
MedLine Citation:
PMID:  23321345     Owner:  NLM     Status:  MEDLINE    
Baclofen reduces intake of some foods but stimulates intake or has no effect on others. The reasons for these differences are not known. The present study examined effects of baclofen when composition, energy density, preference, presentation and intake of optional foods varied. Semi-solid fat emulsions and sucrose products were presented for brief periods to non-food-deprived rats. In Experiment 1, fat and sucrose composition were varied while controlling energy density. In Experiment 2A, schedule of access and the number of optional foods were varied. In Experiment 2B, the biopolymer (thickener) was examined. Baclofen reduced intake of fat and/or sugar options with different energy densities (1.28-9kcal/g), when presented daily or intermittently, and when intakes were relatively high or low. However, the efficacy of baclofen was affected by the biopolymer used to thicken the options: baclofen had no effect when options were thickened with one biopolymer (3173), but reduced intake when options were thickened with another biopolymer (515). Baclofen failed to reduce intake of a concentrated sugar option (64% sucrose), regardless of biopolymer. Based upon these results, caution is urged when interpreting results obtained with products using different thickening agents. Systematic research is needed when designing products used in rat models of food intake.
F H E Wojnicki; G Charny; R L W Corwin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-12
Journal Detail:
Title:  Appetite     Volume:  64     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-22     Completed Date:  2013-09-09     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  62-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Baclofen / pharmacology*
Dietary Fats / administration & dosage
Dietary Sucrose / administration & dosage
Eating / drug effects*
Energy Intake
Food Additives*
Food Preferences / drug effects*
GABA-B Receptor Agonists / pharmacology*
Rats, Sprague-Dawley
Grant Support
Reg. No./Substance:
0/Biopolymers; 0/Dietary Fats; 0/Dietary Sucrose; 0/Food Additives; 0/GABA-B Receptor Agonists; H789N3FKE8/Baclofen

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