| Background review and current concepts of reperfusion injury. | |
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MedLine Citation:
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PMID: 2241624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We define the concept of reperfusion injury, and we present a background chronology of experimental work supporting and questioning this concept. We identify several new influences, such as current clinical interest in thrombolytic therapy for acute ischemia of heart and brain and the growing recognition of endothelium as a regulator of homeostasis. We propose that these influences will encourage a reexamination of reperfusion injury as a factor in the ultimate outcome of tissue exposed to reversible ischemia. We briefly discuss the major mechanisms presently implicated in reperfusion injury--loss of calcium homeostasis, free radical generation, leukocyte-mediated injury, and acute hypercholesterolemia. |
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Authors:
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J M Hallenbeck; A J Dutka |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Archives of neurology Volume: 47 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1990-12-14 Completed Date: 1990-12-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1245-54 Citation Subset: AIM; IM |
Affiliation:
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Neurology Department, National Naval Medical Center, Bethesda, MD 20814-5011. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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metabolism Cholesterol / metabolism Free Radicals Humans Leukocytes / metabolism Oxygen / metabolism Reperfusion Injury / metabolism, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 NS28225-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 57-88-5/Cholesterol; 7440-70-2/Calcium; 7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Arch Neurol 1991 Aug;48(8):811 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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