Document Detail

Background review and current concepts of reperfusion injury.
MedLine Citation:
PMID:  2241624     Owner:  NLM     Status:  MEDLINE    
We define the concept of reperfusion injury, and we present a background chronology of experimental work supporting and questioning this concept. We identify several new influences, such as current clinical interest in thrombolytic therapy for acute ischemia of heart and brain and the growing recognition of endothelium as a regulator of homeostasis. We propose that these influences will encourage a reexamination of reperfusion injury as a factor in the ultimate outcome of tissue exposed to reversible ischemia. We briefly discuss the major mechanisms presently implicated in reperfusion injury--loss of calcium homeostasis, free radical generation, leukocyte-mediated injury, and acute hypercholesterolemia.
J M Hallenbeck; A J Dutka
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Archives of neurology     Volume:  47     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-14     Completed Date:  1990-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1245-54     Citation Subset:  AIM; IM    
Neurology Department, National Naval Medical Center, Bethesda, MD 20814-5011.
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MeSH Terms
Calcium / metabolism
Cholesterol / metabolism
Free Radicals
Leukocytes / metabolism
Oxygen / metabolism
Reperfusion Injury / metabolism,  physiopathology*
Grant Support
1 R01 NS28225-01/NS/NINDS NIH HHS
Reg. No./Substance:
0/Free Radicals; 57-88-5/Cholesterol; 7440-70-2/Calcium; 7782-44-7/Oxygen
Erratum In:
Arch Neurol 1991 Aug;48(8):811

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