Document Detail

Background effects on Faraday collectors in gas-source mass spectrometry and implications for clumped isotope measurements.
MedLine Citation:
PMID:  23413219     Owner:  NLM     Status:  In-Data-Review    
RATIONALE: The measurement of the abundances of minor isotopologues by mass spectrometry requires correction of subtle non-linearities in the mass spectrometer that cause deviations in the relationship between actual and measured isotope ratios. Here we show that negative backgrounds on the Faraday cups recording the minor ion beams are the cause of the observed non-linearities in the measurement of CO(2) isotopologues, and propose a new correction procedure for clumped isotope measurements.
METHODS: We carefully investigated the cause of non-linearity effects in the measurement of the abundance of (13) C(18) O(16) O, a minor isotopologue of CO(2) with m/z 47, on two different mass spectrometers. By using gases of different composition with close to stochastic and with non-random distribution of isotopes we demonstrate that the apparent dependence of the excess abundance of the isotopologue of m/z 47 on the bulk isotopic composition of CO(2) is due to a background interference that is linearly dependent on the partial pressure of the gas in the source of the mass spectrometer.
CONCLUSIONS: Background determination with gas flowing into the source of the mass spectrometer is necessary for accurate clumped isotope measurements of CO(2) . Background corrections can be performed accurately if the slit width of the m/z 44 Faraday cup significantly exceeds that of the one for m/z 47, using a correlation between m/z 44 signal intensity and the corresponding minimum in m/z 47 background. We propose two new correction schemes that reduce the time-consuming measurement of gases of different bulk isotopic compositions. These findings may also be relevant for the measurement of other rare isotopologues by mass spectrometry. Copyright © 2013 John Wiley & Sons, Ltd.
Stefano M Bernasconi; Bin Hu; Ulrike Wacker; Jens Fiebig; Sebastian F M Breitenbach; Tanja Rutz
Related Documents :
12877199 - Column selectivity in reversed-phase liquid chromatography. iv. type-b alkyl-silica col...
16405899 - New small-scale cross-axis coil planet centrifuge. the design of the apparatus and its ...
18067899 - Cluster and principal component analysis for kováts' retention indices on apolar and p...
24596159 - Characterization of green fluorescent proteins by 193 nm ultraviolet photodissociation ...
9711499 - Comparison of partial least-square method and canonical correlation analysis in a quant...
24794939 - Water analysis of the sixteen environmental protection agency-polycyclic aromatic hydro...
25285509 - A two-stage multiplex method for quantitative analysis of botulinum neurotoxin type a, ...
1400799 - Measurement of azacyclonol in urine and serum of humans following terfenadine (seldane)...
21377949 - Bioavailability of cadmium in inexpensive jewelry.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  27     ISSN:  1097-0231     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Geological Institute, ETH Zurich, Sonneggstr. 5, 8092, Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gas chromatography combined with mass spectrometry, flame ionization detection and elemental analyze...
Next Document:  Direct analysis of samples under ambient condition by high-voltage-assisted laser desorption ionizat...