Document Detail

Background diet influences the anti-inflammatory effect of alpha-linolenic acid in dyslipidaemic subjects.
MedLine Citation:
PMID:  15522134     Owner:  NLM     Status:  MEDLINE    
Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of alpha-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean-Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8.1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P<0.001), CRP (P=0.002), MCSF (P=0.005) and IL-6 (P=0.04) concentrations. The Mediterranean-Cretan-type background diet group showed a significant reduction only in MCSF concentrations (P=0.003). The sVCAM-1 concentrations were significantly reduced in both the Westernised Greek diet group (P=0.001) and the Mediterranean-Cretan-type diet group (P<0.001). The present study demonstrated that ALA supplementation lowered the serum concentrations of inflammatory markers more profoundly when the background diet was rich in saturated fatty acids and poor in MUFA.
George K Paschos; Loukianos S Rallidis; Georgios K Liakos; Demosthenes Panagiotakos; George Anastasiadis; Vasilios Votteas; Antonis Zampelas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  92     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2004-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-55     Citation Subset:  IM    
Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Street, Athens 17671, Greece.
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MeSH Terms
Biological Markers / blood
Cell Adhesion Molecules / blood
Diet, Mediterranean
Dietary Supplements*
Hyperlipidemias / blood,  diet therapy*
Inflammation / blood,  diet therapy*
Middle Aged
alpha-Linolenic Acid / therapeutic use*
Reg. No./Substance:
0/Biological Markers; 0/Cell Adhesion Molecules; 463-40-1/alpha-Linolenic Acid

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