| Background Parenchymal Enhancement at Breast MR Imaging and Breast Cancer Risk. | |
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MedLine Citation:
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PMID: 21493794 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To examine the relationships between breast cancer and both amount of fibroglandular tissue (FGT) and level of background parenchymal enhancement (BPE) at magnetic resonance (MR) imaging. Materials and Methods: A waiver of authorization was granted by the institutional review board for this retrospective HIPAA-compliant study. Among 1275 women who underwent breast MR imaging screening between December 2002 and February 2008, 39 breast carcinoma cases were identified. Two comparisons were performed: In one comparison, two normal controls-those of the women with negative (benign) findings at breast MR imaging-were matched to each breast cancer case on the basis of age and date of MR imaging. In the second comparison, one false-positive control-that of a woman with suspicious but nonmalignant findings at MR imaging-was similarly matched to each breast cancer case. Two readers independently rated the level of MR imaging-depicted BPE and the amount of MR imaging-depicted FGT by using a categorical scale: BPE was categorized as minimal, mild, moderate, or marked, and FGT was categorized as fatty, scattered, heterogeneously dense, or dense. Results: Compared with the odds ratio (OR) for a normal control, the OR for breast cancer increased significantly with increasing BPE: The ORs for moderate or marked BPE versus minimal or mild BPE were 10.1 (95% confidence interval [CI]: 2.9, 35.3; P < .001) and 3.3 (95% CI: 1.3, 8.3; P = .006) for readers 1 and 2, respectively. Similar odds were seen when the false-positive controls were compared with the breast cancer cases: The ORs for moderate or marked BPE versus minimal or mild BPE were 5.1 (95% CI: 1.4, 19.1; P = .005) and 3.7 (95% CI: 1.2, 11.2; P = .013) for readers 1 and 2, respectively. The breast cancer odds also increased with increasing FGT, but the BPE findings remained significant after adjustment for FGT. Conclusion: Increased BPE is strongly predictive of breast cancer odds. © RSNA, 2011. |
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Authors:
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Valencia King; Jennifer D Brooks; Jonine L Bernstein; Anne S Reiner; Malcolm C Pike; Elizabeth A Morris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-14 |
Journal Detail:
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Title: Radiology Volume: - ISSN: 1527-1315 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Radiology and Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, Evelyn H. Lauder Breast Center, 300 E 66th St, Room 715, New York, NY 10065. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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