Document Detail


Back to the future: how biology and technology could change the role of PTFE grafts in vascular access management.
MedLine Citation:
PMID:  22908978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the arteriovenous fistula (AVF) is the preferred mode of dialysis vascular access, AVF maturation failure remains a huge clinical problem, often resulting in a prolonged duration of use of tunneled dialysis catheters. In contrast, polytetrafluoroethylene (PTFE) grafts do not suffer from early failure, but have significant problems with later stenosis and thrombosis. This review will initially summarize the pathology and pathogenesis of PTFE graft dysfunction and will then use this as a basis for describing some novel therapies, which may have the potential to reduce PTFE graft dysfunction. Finally, we will emphasize that the introduction of such therapies could be an important first step toward individualizing overall vascular access care.
Authors:
Prabir Roy-Chaudhury; Mahmoud El-Khatib; Begona Campos-Naciff; Davinder Wadehra; Karthik Ramani; Massoud Leesar; Meenakshi Mistry; Yang Wang; Jenq-Shyong Chan; Timmy Lee; Rino Munda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-08-22
Journal Detail:
Title:  Seminars in dialysis     Volume:  25     ISSN:  1525-139X     ISO Abbreviation:  Semin Dial     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-03-12     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-504     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Arteriovenous Shunt, Surgical / adverse effects*
Blood Vessel Prosthesis / adverse effects
Catheters, Indwelling / adverse effects*
Graft Occlusion, Vascular / etiology
Humans
Kidney Failure, Chronic / therapy*
Polytetrafluoroethylene*
Prosthesis Failure
Renal Dialysis*
Thrombosis / etiology
Grant Support
ID/Acronym/Agency:
1R01DK088777/DK/NIDDK NIH HHS; 1R21-DK089280-01/DK/NIDDK NIH HHS; 5R01-EB004527/EB/NIBIB NIH HHS; 5U01-DK82218/DK/NIDDK NIH HHS; 5U01-DK82218S/DK/NIDDK NIH HHS; K23 DK083528/DK/NIDDK NIH HHS; UL1 TR000077/TR/NCATS NIH HHS; UL1RR026314/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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