| Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated beta-amino acid. | |
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MedLine Citation:
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PMID: 20541548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the iturin family. 1D and 2D NMR, as well as MS analyses, identified the beta-amino acid as 3-amino-13-methyltetradec-8-enoic acid, an Iso C15 long chain beta-amino acid. B. subtilis SSE4 was also found to produce iturin A. B. subtilis SSE4 culture filtrate exhibited both antifungal and antibacterial activities. |
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Authors:
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Nopporn Thasana; Benjaphorn Prapagdee; Nuchanart Rangkadilok; Ratiboot Sallabhan; Seaim Lwin Aye; Somsak Ruchirawat; Suvit Loprasert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-10 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3209-14 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Chemical Biology Program, Chulabhorn Graduate Institute, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipic Acids Amino Acids / analysis Anti-Bacterial Agents* Antifungal Agents / isolation & purification, pharmacology Asparagine / metabolism Bacillus subtilis / drug effects Lipids Lipopeptides Magnetic Resonance Spectroscopy Peptides, Cyclic Serine / analogs & derivatives Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adipic Acids; 0/Amino Acids; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Lipids; 0/Lipopeptides; 0/Peptides, Cyclic; 0/serine containing aminolipid; 124-04-9/adipic acid; 52229-90-0/iturin A; 55520-40-6/Tyrosine; 56-45-1/Serine; 7006-34-0/Asparagine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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