| Baby on board: do responses to stress in the maternal brain mediate adverse pregnancy outcome? | |
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MedLine Citation:
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PMID: 20546772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stress and adverse environmental surroundings result in suboptimal conditions in a pregnant mother such that she may experience poor pregnancy outcome including complete pregnancy failure and preterm labor. Furthermore her developing baby is at risk of adverse programming, which confers susceptibility to long term ill health. While some mechanisms at the feto-maternal interface underlying these conditions are understood, the underlying cause for their adverse adaptation is often not clear. Progesterone plays a key role at many levels, including control of neuroendocrine responses to stress, procuring the required immune balance and controlling placental and decidual function, and lack of progesterone can explain many of the unwanted consequences of stress. How stress that is perceived by the mother inhibits progesterone secretion and action is beginning to be investigated. This overview of maternal neuroendocrine responses to stress throughout pregnancy analyses how they interact to compromise progesterone secretion and precipitate undesirable effects in mother and offspring. |
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Authors:
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Alison J Douglas |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-05-31 |
Journal Detail:
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Title: Frontiers in neuroendocrinology Volume: 31 ISSN: 1095-6808 ISO Abbreviation: Front Neuroendocrinol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513292 Medline TA: Front Neuroendocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 359-76 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, United Kingdom. alison.j.douglas@ed.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism, physiopathology* Female Humans Infant, Newborn Models, Biological Mothers / psychology Neurosecretory Systems / metabolism, physiology Pregnancy Pregnancy Outcome* Prenatal Exposure Delayed Effects / metabolism, physiopathology* Stress, Psychological / metabolism, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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