Document Detail


Babesia caballi and Babesia equi: implications of host sialic acids in erythrocyte infection.
MedLine Citation:
PMID:  15869756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigated the involvement of host sialic acids in the erythrocyte infection by two equine Babesia parasites, Babesia equi and Babesia caballi. We observed that the in vitro growth of both parasites is influenced by the removal of sialic acids from the surface of equine erythrocytes (RBC). When the parasites were cultured with neuraminidase (Nm, EC 3.2.1.18)-treated RBC, in which alpha2-3-linked sialic acid residues were removed from four membrane proteins of the RBC, B. caballi showed a significant inhibition of the erythrocyte invasion, while the intracellular development of B. equi seemed to be significantly affected. The possible involvement of host sialic acid in the erythrocyte invasion by B. caballi was also supported by a significant reduction in the parasite growth accompanied by an increased number of extracellular merozoites after the addition of exogenous 3'-sialyllactose (Neu5Acalpha(2-3)Galbeta(1-4)Glc) into the culture. These results suggest that the alpha2-3-linked sialic acid residues on host RBC play important roles in the erythrocyte infections by B. caballi and B. equi.
Authors:
Masashi Okamura; Naoaki Yokoyama; Nilanthi P A L K Wickramathilaka; Noriyuki Takabatake; Yuzuru Ikehara; Ikuo Igarashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental parasitology     Volume:  110     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-11     Citation Subset:  IM    
Affiliation:
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Hokkaido, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Babesia / growth & development,  physiology*
Babesiosis / blood,  parasitology,  veterinary
Electrophoresis, Polyacrylamide Gel
Erythrocytes / chemistry,  parasitology*
Horse Diseases / blood,  parasitology
Horses
Neuraminidase / metabolism
Parasitemia / blood,  parasitology,  veterinary
Sialic Acids / metabolism,  physiology*
Chemical
Reg. No./Substance:
0/Sialic Acids; EC 3.2.1.18/Neuraminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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