| Ba++ as a gastric stimulant: release of histamine. | |
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MedLine Citation:
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PMID: 55079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ba++ added to the serosal solution bathing a resting frog stomach increased transmucosal resistance and induced acid secretion. The increase in acid secretion was associated with an increased leak of histamine from the mucosa into the serosal solution. Pretreatment with burimamide inhibited the secretory response to Ba++. After a pulse treatment with Ba++ (2 mM for 5 min), the effects on resistance were transient but the effects on acid secretion were sustained. A pulse treatment with histamine also led to a sustained increase in acid secretion, and this increase was blocked by burimamide. It is concluded that Ba++ releases histamine which then stimulates acid secretion. |
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Authors:
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P K Rangachari |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 229 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Sep |
Date Detail:
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Created Date: 1976-03-11 Completed Date: 1976-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 627-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anura Barium / pharmacology* Burimamide / pharmacology Gastric Juice / drug effects* Gastric Mucosa / drug effects Histamine / pharmacology Histamine Release / drug effects* Rana catesbeiana Secretory Rate / drug effects Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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34970-69-9/Burimamide; 51-45-6/Histamine; 7440-39-3/Barium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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