Document Detail


BZS1, a B-box protein, promotes photomorphogenesis downstream of both brassinosteroid and light signaling pathways.
MedLine Citation:
PMID:  22535582     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photomorphogenesis is controlled by multiple signaling pathways, including the light and brassinosteroid (BR) pathways. BR signaling activates the BZR1 transcription factor, which is required for suppressing photomorphogenesis in the dark. We identified a suppressor of the BR hypersensitive mutant bzr1-1D and named it bzr1-1D suppressor1-Dominant (bzs1-D). The bzs1-D mutation was caused by overexpression of a B-box zinc finger protein BZS1, which is transcriptionally repressed by BZR1. Overexpression of BZS1 causes de-etiolation in the dark, short hypocotyls in the light, reduced sensitivity to BR treatment, and repression of many BR-activated genes. Knockdown of BZS1 by co-suppression partly suppressed the short hypocotyl phenotypes of BR-deficient or insensitive mutants. These results support that BZS1 is a negative regulator of BR response. BZS1 overexpressors are hypersensitive to different wavelengths of light and loss of function of BZS1 reduces plant sensitivity to light and partly suppresses the constitutive photomorphogenesis 1 (cop1) mutant in the dark, suggesting a positive role in light response. BZS1 protein accumulates at an increased level after light treatment of dark-grown BZS1-OX plants and in the cop1 mutants, and BZS1 interacts with COP1 in vitro, suggesting that light regulates BZS1 through COP1-mediated ubiquitination and proteasomal degradation. These results demonstrate that BZS1 mediates the crosstalk between BR and light pathways.
Authors:
Xi-Ying Fan; Yu Sun; Dong-Mei Cao; Ming-Yi Bai; Xiao-Min Luo; Hong-Juan Yang; Chuang-Qi Wei; Sheng-Wei Zhu; Ying Sun; Kang Chong; Zhi-Yong Wang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-25
Journal Detail:
Title:  Molecular plant     Volume:  5     ISSN:  1752-9867     ISO Abbreviation:  Mol Plant     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-09-13     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  101465514     Medline TA:  Mol Plant     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-600     Citation Subset:  IM    
Affiliation:
Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics,  growth & development*,  radiation effects*
Arabidopsis Proteins / genetics,  metabolism*
Brassinosteroids / metabolism*
Gene Expression Regulation, Plant / radiation effects
Genes, Plant / genetics
Genes, Suppressor
Light*
Morphogenesis / genetics,  radiation effects*
Mutation / genetics
Phenotype
Signal Transduction / genetics,  radiation effects*
Transcription Factors / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
R01 GM066258/GM/NIGMS NIH HHS; R01GM066258/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/BZS1 protein, Arabidopsis; 0/Brassinosteroids; 0/Transcription Factors
Comments/Corrections

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