| BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. | |
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MedLine Citation:
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PMID: 19882345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The butyrophilin-like 2 (BTNL2) gene is a member of the B7 receptor family that probably functions as a T cell costimulatory molecule. Because altered T cell functions are implicated in dysregulation of the immune response seen in Kawasaki disease (KD), it is reasonable to speculate that BTNL2 gene is involved in the pathophysiology of KD. The purpose of this study was to investigate whether polymorphisms of the BTNL2 gene are associated with KD and the development of coronary artery lesions (CALs) in Taiwanese children. Nine-three patients with KD and 669 ethnically matched healthy controls were genotyped for BTNL2 gene rs1555115 C/G and rs2395158 A/G polymorphisms. The frequency of GG genotype of rs 1555115 was significantly higher in KD patients compared with controls (2.2% vs 0.2%, P = 0.012). The odds ratio for developing KD in individuals with rs 1555115 GG genotype was 14.7 (95% confidence interval, 2.04-105.5, P = 0.003) compared with individuals with rs 1555115 CG and CC genotypes. No significant difference was observed in the genotype and allelic frequencies of rs 2395158 polymorphism between KD patients and controls. However, the frequency of the G allele of rs 2395158 was significantly higher in KD patients with CALs than in those without CALs (P = 0.001). No significant difference was observed in the genotype and allelic frequencies of rs 1555115 polymorphism between KD patients with and without CALs. In conclusion, our results suggest that BTNL2 gene polymorphisms might be genetic markers of KD susceptibility and risk of coronary artery complication in Taiwanese children. |
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Authors:
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Kai-Chung Hsueh; Ying-Ju Lin; Jeng-Sheng Chang; Lei Wan; Fuu-Jen Tsai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-01 |
Journal Detail:
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Title: European journal of pediatrics Volume: 169 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 713-9 Citation Subset: IM |
Affiliation:
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Children's Medical Center, China Medical University Hospital, Taichung, Taiwan. kh233262@ms38.hinet.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asian Continental Ancestry Group
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genetics* Case-Control Studies Child Child, Preschool Coronary Disease / ethnology, genetics* Female Genetic Markers Genetic Predisposition to Disease / genetics Humans Infant Linkage Disequilibrium Male Membrane Glycoproteins / genetics* Mucocutaneous Lymph Node Syndrome / ethnology, genetics* Polymorphism, Genetic* Taiwan / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/BTNL2 protein, human; 0/Genetic Markers; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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