| BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings. | |
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MedLine Citation:
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PMID: 20395873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Midline carcinoma with chromosomal rearrangement of the gene nuclear protein in testis (NUT) is termed NUT midline carcinoma (NMC), and is a rare and highly lethal neoplasm. The gene BRD4 is its most common translocation partner, forming a BRD4-NUT fusion oncogene. NMCs typically occur in the midline, most commonly in the head, neck, or mediastinum, as poorly differentiated carcinomas with variable degrees of squamous differentiation. This is a recently characterized tumor, and thus is still largely unfamiliar to radiologists. We report a 10-year-old boy with NMC involving the posterior mediastinum and invading the left pulmonary vein with an extension into the left atrium; these findings are presented with an emphasis on multidetector computed tomography imaging. |
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Authors:
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Benjamin A Nelson; Edward Y Lee; Christopher A French; Daniel E Bauer; Sara O Vargas |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of thoracic imaging Volume: 25 ISSN: 1536-0237 ISO Abbreviation: J Thorac Imaging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606160 Medline TA: J Thorac Imaging Country: United States |
Other Details:
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Languages: eng Pagination: W93-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma
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diagnosis*,
radiography Child Humans Male Mediastinal Neoplasms / diagnosis*, metabolism, radiography Nuclear Proteins / metabolism* Oncogene Proteins, Fusion / metabolism* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/BRD4-NUT fusion oncogene protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins, Fusion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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