Document Detail

BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings.
MedLine Citation:
PMID:  20395873     Owner:  NLM     Status:  MEDLINE    
Midline carcinoma with chromosomal rearrangement of the gene nuclear protein in testis (NUT) is termed NUT midline carcinoma (NMC), and is a rare and highly lethal neoplasm. The gene BRD4 is its most common translocation partner, forming a BRD4-NUT fusion oncogene. NMCs typically occur in the midline, most commonly in the head, neck, or mediastinum, as poorly differentiated carcinomas with variable degrees of squamous differentiation. This is a recently characterized tumor, and thus is still largely unfamiliar to radiologists. We report a 10-year-old boy with NMC involving the posterior mediastinum and invading the left pulmonary vein with an extension into the left atrium; these findings are presented with an emphasis on multidetector computed tomography imaging.
Benjamin A Nelson; Edward Y Lee; Christopher A French; Daniel E Bauer; Sara O Vargas
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of thoracic imaging     Volume:  25     ISSN:  1536-0237     ISO Abbreviation:  J Thorac Imaging     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606160     Medline TA:  J Thorac Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W93-6     Citation Subset:  IM    
Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, MA, USA.
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MeSH Terms
Carcinoma / diagnosis*,  radiography
Mediastinal Neoplasms / diagnosis*,  metabolism,  radiography
Nuclear Proteins / metabolism*
Oncogene Proteins, Fusion / metabolism*
Tomography, X-Ray Computed
Reg. No./Substance:
0/BRD4-NUT fusion oncogene protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins, Fusion

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