Document Detail


BRCA1 and BRCA2 mutations and female fertility.
MedLine Citation:
PMID:  23411475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To review recent publications examining BRCA1 and BRCA2 mutations and their relationship with female fertility.
RECENT FINDINGS: Eight relevant studies of female fertility, five of which were published since January 2010 and the remainder in the preceding decade. Several mechanisms suggest that reproduction will be adversely affected among BRCA1/2 mutation carriers, with one study finding lower oocyte production, another reporting fewer births, and a third showing lower rates of pregnancies. Four articles reported no significant difference in the number of children ever born between carriers and noncarriers whereas a 2012 study showed elevated natural fertility among mutation carriers.
SUMMARY: This review shows that for most articles there are adverse or no fertility effects of being a BRCA1/2 mutation carrier. When no differences were detected for children-ever-born, those studies relied on current populations in which women had access to contraception. The sole analysis reporting elevated fertility was based on an historic population in which family planning methods were unavailable. Predictions that BRCA1/2 mutations adversely affect embryogenesis and genome integrity were not supported. The idea that BRCA1/2 mutations have antagonistic pleiotropic effects (enhancing fertility while reducing survival) was supported in the natural fertility study.
Authors:
Ken R Smith; Heidi A Hanson; Michael S Hollingshaus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  25     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-02     Completed Date:  2013-12-10     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / genetics*
Female
Genes, BRCA1*
Genes, BRCA2*
Genetic Pleiotropy
Genetic Predisposition to Disease
Heterozygote
Heterozygote Detection
Humans
Infertility, Female / diagnosis,  genetics*
Mutation*
Oocytes
Ovarian Neoplasms / genetics*
Pregnancy
Pregnancy Rate
Risk Factors
Grant Support
ID/Acronym/Agency:
AG022095/AG/NIA NIH HHS; R01 AG022095/AG/NIA NIH HHS
Comments/Corrections

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