| The BRC repeats are conserved in mammalian BRCA2 proteins. | |
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MedLine Citation:
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PMID: 9002670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The breast cancer susceptibility gene BRCA2 encodes a protein of 3418 amino acids which does not exhibit substantial sequence similarity to any other protein in the public databases. A dot matrix comparison of BRCA2 with itself revealed an eight times repeated motif in the segment of the protein encoded by exon 11. As a preliminary test of the hypothesis that these motifs are functionally significant, we have sequenced exon 11 of BRCA2 in six mammals. An alignment of the predicted protein sequences shows that, overall, the motifs have been conserved while much of the intervening sequences has diverged. These data support the notion that the BRC motifs are important in BRCA2 function. There is, however, considerable interspecies variation within certain motif units, raising the possibility of redundancy and that not all of the repeats are required for the normal function of BRCA2. |
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Authors:
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G Bignell; G Micklem; M R Stratton; A Ashworth; R Wooster |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human molecular genetics Volume: 6 ISSN: 0964-6906 ISO Abbreviation: Hum. Mol. Genet. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-03-26 Completed Date: 1997-03-26 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 9208958 Medline TA: Hum Mol Genet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, UK. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/Z75664; Z75665; Z75666; Z75667 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals BRCA2 Protein Base Sequence Conserved Sequence* Cricetinae DNA Dogs Exons* Haplorhini Humans Mammals Mice Molecular Sequence Data Neoplasm Proteins / genetics* Repetitive Sequences, Nucleic Acid* Sequence Homology, Amino Acid Swine Transcription Factors / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/BRCA2 Protein; 0/Neoplasm Proteins; 0/Transcription Factors; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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