Document Detail

BRAFO tiered approach for benefit-risk assessment of foods.
MedLine Citation:
PMID:  20546818     Owner:  NLM     Status:  In-Data-Review    
BRAFO stands for Benefit-Risk Analysis for Foods. This European Commission funded project aims at developing a framework that allows quantitative comparison of human health risks and benefits of foods and food compounds based on a common scale of measurement. A methodology group brought together methodologies from several disciplines relevant to the evaluation of risks and benefits in food. This group reviewed and assembled the methodologies available. They produced this guidance document that describes a tiered ('stepwise') approach for performing a risk and benefit assessment of foods. This process starts with pre-assessment and problem formulation to set the scope of the assessment. This includes defining two scenarios, the reference and an alternative that are compared in the assessment. The approach consists of four tiers. In many cases, a lower tier assessment in which risks and benefits are qualitatively evaluated may be sufficient to show a clear difference between the health impacts of the two scenarios. In other cases, increasingly sophisticated methods to integrate risks and benefits quantitatively are used at higher tiers to assess the net health impact.
Jeljer Hoekstra; Andy Hart; Alan Boobis; Erika Claupein; Andrew Cockburn; Alistair Hunt; Ib Knudsen; David Richardson; Benoît Schilter; Katrin Schütte; Paul R Torgerson; Hans Verhagen; Bernhard Watzl; Alessandro Chiodini
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Publication Detail:
Type:  Journal Article     Date:  2010-05-28
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  50 Suppl 4     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S684-98     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.
National Institute for Public Health and the Environment (RIVM), 3720 BA, Bilthoven, The Netherlands.
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