| BRAF status of follicular variant of papillary thyroid carcinoma and its relationship to its clinical and cytological features. | |
| | |
MedLine Citation:
|
PMID: 20950194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The cytological discrimination between benign and malignant follicular-patterned lesions of the thyroid can represent a diagnostic challenge, even for experienced pathologists. To attempt to clarify this diagnostic problem, we analyzed the BRAF status of thyroid tumors in a group of patients with follicular variant of papillary thyroid carcinoma (FVPTC) and its correlation with cytomorphological features. METHODS: The BRAF status was evaluated in a total of 187 patients in whom FVPTC was consecutively diagnosed by histology between January 2006 and January 2009. Each case had a previous fine-needle aspiration diagnosis classified according to the British Thyroid Association Guidelines categorized as inadequate (Thy1) (n = 19), benign (Thy2) (n = 19), follicular lesion and follicular lesion with atypia (Thy3) (n = 109), suspicious of PTC (Thy4) (n = 29), or malignant (Thy5) (n = 11). The first 68 cases were selected for a morphological study by a quantitative analysis of four cytological features (grooves, intranuclear cytoplasmatic inclusions, number of cells per high power field (400 ×), and mean nuclear diameter) of the carcinomas. RESULTS: The BRAF status of each tumor was correlated with the cytological classes. 54.5% and 27.6% of Thy5 and Thy4, respectively, were BRAF-mutated, against 12.1% of follicular lesions and 9.3% of follicular lesion with atypia (Thy3). This comparison was statistically significative (p = 0.0017). Among the 68 cases selected for the cyto-morphological study, the BRAF status frequency was similar to that of the total case series. No significant differences were found correlating the cytological classes with the number of cells, the number of grooves, and the mean cell diameters. Only the number of intranuclear cytoplasmatic inclusions were associated (p < 0.05) with the Thy5 cytological class. CONCLUSIONS: BRAF is mutated in a low percentage of FVPTC, and most of these mutated cases are suspicious or positive on fine-needle aspiration. BRAF analysis is of limited value in the preoperative diagnosis of FVPTC. |
| | |
Authors:
|
Agnese Proietti; Riccardo Giannini; Clara Ugolini; Mario Miccoli; Gabriella Fontanini; Giancarlo Di Coscio; Rossana Romani; Piero Berti; Paolo Miccoli; Fulvio Basolo |
Related Documents
:
|
3079564 - Histopathologic study of the so called 'palpation thyroiditis'. 10097724 - Diagnosing invasive cystic hypersecretory duct carcinoma of the breast with fine needle... 6088894 - Tracheal carcinoma presenting as a thyroid tumor. 20535424 - An audit study of the sensitivity and specificity of ultrasound, fine needle aspiration... 683914 - Pancreatitis and duodenal obstruction due to periampullary carcinoma associated with fa... 21985734 - Laparoscopic management of chemical peritonitis caused by dermoid cyst spillage. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-17 |
Journal Detail:
|
Title: Thyroid : official journal of the American Thyroid Association Volume: 20 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-10 Completed Date: 2011-03-07 Revised Date: 2012-06-21 |
Medline Journal Info:
|
Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
|
Languages: eng Pagination: 1263-70 Citation Subset: IM |
Affiliation:
|
Division of Pathology, Department of Surgery, University of Pisa, Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma, Follicular
/
genetics,
pathology Adolescent Adult Aged Carcinoma, Papillary / genetics, pathology* Diagnosis, Differential Female Humans Male Middle Aged Proto-Oncogene Proteins B-raf / genetics* Thyroid Gland / pathology Thyroid Neoplasms / genetics, pathology* Thyroid Nodule / pathology Tumor Markers, Biological / genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solanum paniculatum L. leaf and fruit extracts: assessment of modulation of cytotoxicity and genotox...
Next Document: The 'difficult' nurse-patient relationship: development and evaluation of an e-learning package.