| BORIS, Brother of the Regulator of Imprinted Sites, Is Aberrantly Expressed in Hepatocellular Carcinoma. | |
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MedLine Citation:
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PMID: 23237599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The brother of the regulator of imprinted sites (BORIS) is a novel member of the cancer testis antigen gene family, which are normally expressed only in spermatocytes, but abnormally activated in different malignancies. Aim: The aim of this study was to explore the expression of BORIS in hepatocellular carcinoma (HCC) and its correlation with the clinicopathologic features and prognosis of HCC. Methods: We investigated BORIS expression in HCC cell lines and 105 primary HCC clinical surgical specimens using real-time polymerase chain reaction and Western blot analysis. We further examined the correlation of BORIS with a liver stem cell marker (CD90) in HCC tissues by histochemical double staining. The correlation of BORIS with clinicopathologic features and prognosis of HCC was analyzed using patient data. Results: The expression of BORIS was found in SMMC-7721, BEL-7402, and Huh-7, but not in hep-G2 cells. The expression rate of BORIS was significantly higher in the HCC tissues than in the adjacent noncancerous tissues (p=0.000). BORIS expression was correlated with the tumor size (p=0.000), CD90 expression (p=0.000), and satellite nodule (p=0.000). Kaplan-Meier survival curves showed that patients with positive expression of BORIS had lower overall survival rate (p=0.003). Conclusions: Our data indicate that BORIS may be an auxiliary diagnosis index and a novel favorable prognostic indicator of HCC. |
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Authors:
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Kefei Chen; Wenqing Huang; Bin Huang; Yonggang Wei; Bo Li; Yan Ge; Yang Qin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-13 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: - ISSN: 1945-0257 ISO Abbreviation: Genet Test Mol Biomarkers Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Division of Liver Transplantation, Department of Surgery, West China Hospital , Chengdu, China . |
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