Document Detail


The BOLD fMRI refractory effect is specific to stimulus attributes: evidence from a visual motion paradigm.
MedLine Citation:
PMID:  15325388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Functional magnetic resonance imaging (fMRI) studies have demonstrated that the blood oxygenation level-dependent (BOLD) hemodynamic response (HDR) to a stimulus is reduced by the previous presentation of a similar stimulus. We investigated the dependence of this refractory effect upon stimulus characteristics using a novel adaptation paradigm while scanning subjects using fMRI at 4 T. The stimuli were composed of horizontal stripes that scrolled up, scrolled down, or remained static, randomly presented for 1-s duration with stimulus-onset asynchronies (SOAs) of 2-7 s. We identified regions of interest (ROI) in lateral temporal--occipital cortex that were activated by motion stimuli, regardless of direction or SOA. We found strong evidence for direction specificity in motion-sensitive lateral temporal-occipital (LTO) cortex. For stimuli whose direction of motion reprised that of the previous stimulus (e.g., up preceded by up), the fMRI response was attenuated at short SOAs (2-4 s) compared to long SOAs (5-7 s). However, for stimuli whose direction of motion was opposite that of the previous stimulus (e.g., up preceded by down), little or no refractory effect was observed. Additionally, examination of activity in pericalcarine cortex indicated a similar pattern. We conclude that the fMRI refractory effect predominantly reflects local stimulus-specific neuronal or neurovascular adaptation and is unlikely to be a nonspecific response of large vessels that support broad functional regions.
Authors:
Scott A Huettel; Olufolajimi O Obembe; Allen W Song; Marty G Woldorff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  NeuroImage     Volume:  23     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-11-30     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-8     Citation Subset:  IM    
Affiliation:
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, USA. scott.huettel@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Magnetic Resonance Imaging*
Male
Motion Perception / physiology*
Occipital Lobe / blood supply,  physiology*
Orientation / physiology*
Oxygen / blood*
Pattern Recognition, Visual / physiology*
Reference Values
Refractory Period, Electrophysiological / physiology
Regional Blood Flow / physiology
Temporal Lobe / blood supply,  physiology*
Grant Support
ID/Acronym/Agency:
DA16214/DA/NIDA NIH HHS; P01 41328-PR2/PR/OCPHP CDC HHS; R01 60415//PHS HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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