Document Detail


BOLD MRI in sheep fetuses: a non-invasive method for measuring changes in tissue oxygenation.
MedLine Citation:
PMID:  19771583     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this descriptive study was to correlate changes in the blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) signal with direct measurements of fetal tissue oxygenation. METHODS: Seven anesthetized ewes carrying singleton fetuses at 125 days' gestation (term 145 days) underwent BOLD MRI, covering the entire fetus in a multislice approach. The fetuses were subjected to normoxic, hypoxic and hyperoxic conditions by changing the O(2)/N(2)O ratio in the maternal ventilated gas supply. The partial pressure of oxygen (pO2) in the fetal liver was measured using an oxygen-sensitive optode. Maternal arterial blood samples were simultaneously withdrawn for blood gas analysis. These measurements were compared with BOLD MRI signals in the fetal liver, kidney, spleen and brain. RESULTS: We demonstrated a consistent increase in the BOLD MRI signal with increasing tissue pO(2). For the fetal liver, spleen and kidney we observed a clear association between changes in maternal arterial blood pO2 and changes in BOLD MRI signal. Interestingly, we found that the BOLD signal of the fetal brain remained unchanged during hypoxic, normoxic and hyperoxic conditions. CONCLUSIONS: This experimental study demonstrated that BOLD MRI is a reliable non-invasive method for measuring changes in tissue oxygenation in fetal sheep. The unchanged signal in the fetal brain during altered maternal oxygen conditions is probably explained by the brain-sparing mechanism.
Authors:
A Sørensen; M Pedersen; A Tietze; L Ottosen; L Duus; N Uldbjerg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  34     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  687-92     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Gynecology and Obstetrics, Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark. anne.soerensen@ki.au.dk
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