Document Detail

The BNP assay does not identify mild left ventricular diastolic dysfunction in asymptomatic diabetic patients.
MedLine Citation:
PMID:  15886060     Owner:  NLM     Status:  MEDLINE    
AIMS: We examined the usefulness of BNP for screening for left ventricular (LV) diastolic dysfunction in a sample of type 2 diabetic patients, without structural heart disorder, who have never presented symptoms or signs of heart failure (HF). METHODS AND RESULTS: Seventy-six consecutive patients admitted to the Outpatient Diabetes Clinic were studied. Blood samples were analyzed using the Triage BNP fluorescence immunoassay (Biosite Diagnostics, La Jolla, CA, USA). Echocardiography examinations were performed, with no knowledge of the BNP value. A total of 39 patients out of 76 (51%) were diagnosed with LV diastolic dysfunction and 23 (30%) with LV hypertrophy. Of the patients with LV diastolic dysfunction, impaired relaxation and pseudonormal pattern accounted for 97 and 3% of the cases, respectively. BNP levels among subjects with LV diastolic dysfunction (26+/-22 pg/ml, n=39) were not significantly different from patients with normal LV function (24+/-23 pg/ml, n=37 pg/ml; Mann-Whitney U-test, Z=-0.4, n.s.). CONCLUSIONS: Our data confirm alarmingly high prevalence of LV diastolic dysfunction in asymptomatic individuals with diabetes. Identification of patients with preclinical diabetic cardiomyopathy should be a research and clinical priority. BNP levels cannot be used to detect mild LV diastolic dysfunction in this subset of patients, which requires Doppler echocardiography to be detected.
R Valle; E Bagolin; C Canali; P Giovinazzo; S Barro; N Aspromonte; E Carbonieri; L Milani
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  7     ISSN:  1525-2167     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-27     Completed Date:  2006-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
Heart Failure Centre, Cardiology Unit, Ospedale Civile, Via Sauro 26, San Donà di Piave, I-30027 VE, Italy.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Case-Control Studies
Creatinine / blood
Diabetes Mellitus, Type 2 / blood*,  physiopathology*,  ultrasonography
Echocardiography, Doppler
Fluorescence Polarization Immunoassay
Hypertrophy, Left Ventricular / blood,  physiopathology,  ultrasonography
Middle Aged
Natriuretic Peptide, Brain / blood*
Sensitivity and Specificity
Severity of Illness Index
Ventricular Dysfunction, Left / blood*,  physiopathology*,  ultrasonography
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine

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