| BNP as marker of heart dysfunction in patients with liver cirrhosis. | |
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MedLine Citation:
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PMID: 20729741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUNDS: Patients with liver cirrhosis suffer various degrees of cardiac dysfunction which may be crucial in determining the outcome of surgery. The aim of this study was to determine the role of natriuretic peptides on the assessment of cardiac dysfunction in patients with liver cirrhosis. METHODS: Prospective longitudinal study of 30 patients with hepatic cirrhosis. Severity of disease was assessed according to the Child-Turcotte-Pugh and Model for End Stage Liver Disease (MELD) scores. Cardiac function was assessed using endocrine markers [atrial natriuretic peptide-brain natriuretic peptide (BNP)] and isotopic ventriculography at baseline and after stimulation with dobutamine. RESULTS: The ejection fraction was higher in patients with Child A+B and MELD less than 18 than in patients with advanced liver disease. A significant correlation between BNP plasma levels and MELD values was observed. Dobutamine induced a marked improvement in myocardial performance associated to a decrease in BNP levels. Multivariate analysis showed that BNP has prognostic value as a marker of cardiac ejection fraction. Patients whose baseline BNP concentrations were more than 70 pg/ml had an ejection fraction of around 45%. CONCLUSION: This study has shown that increased baseline BNP concentrations may be regarded together with high Child and MELD scores, as the critical cardiac dysfunction threshold in cirrhotic patients. |
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Authors:
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Javier Padillo; Pilar Rioja; María C Muñoz-Villanueva; Juan A Vallejo; Rubén Ciria; Jordi Muntane; Antonio Sitges-Serra; Guillermo Solórzano; Manuel De la Mata |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 22 ISSN: 1473-5687 ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 1331-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Virgen del Rocío University Hospital-IBiS, Sevilla, Spain. javierpadiruiz@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Natriuretic Factor / blood Biological Markers / blood Blood Pressure Dobutamine / diagnostic use Female Heart Diseases / blood, diagnosis, etiology*, physiopathology Heart Rate Humans Liver Cirrhosis / blood, complications*, physiopathology Longitudinal Studies Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood* Predictive Value of Tests Prospective Studies Radionuclide Ventriculography Severity of Illness Index Spain Stroke Volume |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 34368-04-2/Dobutamine; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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