| BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells. | |
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MedLine Citation:
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PMID: 17273740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enhanced cell migration and invasion play key roles in cancer metastasis. However, the molecules involved in this process are not fully understood. In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with low metastatic potential (MHCC97-L). The in vitro and in vivo effects of BNIPL-2 on cell invasion and metastasis were examined. In vitro analysis showed that the overexpression of BNIPL-2 increases cell invasion and promotes cell migration. The rates of intrahepatic and pulmonary metastasis in nude mice were also increased. Cdc42 activation assays and immunoblot analysis indicated that the activation of Cdc42 and the upregulation of CD44 were involved in the metastasis of cancer cells. The overexpression of BNIPL-2 promotes the invasion and metastasis of MHCC97-L cells. Thus, BNIPL-2 is a gene related with cancer metastasis. |
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Authors:
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Li Xie; Wenxin Qin; Jinjun Li; Xianghuo He; Haitao Zhang; Genfu Yao; Huiqun Shu; Ming Yao; Dafang Wan; Jianren Gu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 17 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-02 Completed Date: 2007-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 605-10 Citation Subset: IM |
Affiliation:
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National Laboratory for Oncogenes and Related Genes, WHO Collaborating Center for Research on Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai 200032, P.R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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biosynthesis* Animals Carcinoma, Hepatocellular / metabolism, pathology* Cell Line, Tumor Humans Immunoblotting Liver Neoplasms / metabolism, pathology* Mice Mice, Nude Neoplasm Invasiveness* Neoplasm Metastasis* Neoplasms, Experimental / pathology Transfection |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/BNIPL protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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