Document Detail


BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development.
MedLine Citation:
PMID:  18924235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endocardial cushions play a critical role in septation of the four-chambered mammalian heart and in the formation of the valve leaflets that control blood flow through the heart. Within the outflow tract (OFT), both cardiac neural crest and endocardial-derived mesenchymal cells contribute to the endocardial cushions. Bone morphogenetic protein 4 (BMP4) is required for endocardial cushion development and for normal septation of the OFT. In the present study, we show that anterior heart field (AHF)-derived myocardium is an essential source of BMP4 required for normal endocardial cushion expansion and remodeling. Loss of BMP4 from the AHF in mice results in an insufficient number of cells in the developing OFT endocardial cushions, defective cushion remodeling, ventricular septal defects, persistent truncus arteriosus, and abnormal semilunar valve formation.
Authors:
David J McCulley; Ji-One Kang; James F Martin; Brian L Black
Related Documents :
6830665 - Accessory tricuspid valve tissue causing obstruction of the ventricular septal defect i...
12440635 - Atrial septal defect and myocardial infarct.
11605775 - Myocardial ischemia induced by anomalous aortic origin of the right coronary artery in ...
15705145 - Transcatheter closure of a complex postmyocardial infarction ventricular septal defect ...
22513225 - Development of a virtual tool for monitoring quality of care in acute myocardial infarc...
21937275 - Coronary artery bypass surgery provides long-term results superior to percutaneous coro...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  237     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2009-02-23     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3200-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Wiley-Liss, Inc.
Affiliation:
Cardiovascular Research Institute, University of California, San Francisco, California 94158-2517, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Septum / cytology,  embryology*
Bone Morphogenetic Protein 4 / biosynthesis*,  genetics
Endocardial Cushions / cytology,  embryology*
Heart Septum / cytology,  embryology*
Heart Valves / cytology,  metabolism*
Mesoderm / cytology,  embryology
Mice
Mice, Knockout
Neural Crest / cytology,  embryology
Grant Support
ID/Acronym/Agency:
HD12324/HD/NICHD NIH HHS; HL64658/HL/NHLBI NIH HHS; P01 HL089707-01A1/HL/NHLBI NIH HHS; R01 HL064658-08/HL/NHLBI NIH HHS; R01 HL064658-09A1/HL/NHLBI NIH HHS; T32 HD007162-26/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Bmp4 protein, mouse; 0/Bone Morphogenetic Protein 4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expression of AP-2delta in the developing chick retina.
Next Document:  Biphasic Ngn3 expression in the developing pancreas.