Document Detail

BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart.
MedLine Citation:
PMID:  20708592     Owner:  NLM     Status:  MEDLINE    
The coronary vessels and epicardium arise from an extracardiac rudiment called the proepicardium. Failed fusion of the proepicardium to the heart results in severe coronary and heart defects. However, it is unknown how the proepicardium protrudes toward and attaches to the looping heart tube. Here, we show that ectopic expression of BMP ligands in the embryonic myocardium can cause proepicardial cells to target aberrant regions of the heart. Additionally, misexpression of a BMP antagonist, Noggin, suppresses proepicardium protrusion and contact with the heart. Finally, proepicardium explant preferentially expands toward a cocultured heart segment. This preference can be mimicked by BMP2/4 and suppressed by Noggin. These results support a model in which myocardium-derived BMP signals regulate the entry of coronary progenitors to the specific site of the heart by directing their morphogenetic movement.
Yasuo Ishii; Robert J Garriock; Alicia M Navetta; Laura E Coughlin; Takashi Mikawa
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental cell     Volume:  19     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-09-13     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-16     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Bone Morphogenetic Proteins / metabolism*
Carrier Proteins / genetics,  metabolism
Chick Embryo
Coronary Vessels / cytology,  embryology*
Heart / anatomy & histology,  embryology*,  physiology
Morphogenesis / physiology
Myocardium / cytology,  metabolism
Paracrine Communication
Pericardium / cytology,  embryology*
Signal Transduction / physiology*
Stem Cells / physiology*
Grant Support
R01 HL078921/HL/NHLBI NIH HHS; R01 HL078921-06/HL/NHLBI NIH HHS; R01 HL078921-07/HL/NHLBI NIH HHS; R01 HL078921-08/HL/NHLBI NIH HHS; R01 HL092429/HL/NHLBI NIH HHS; R01 HL092429-02/HL/NHLBI NIH HHS; R01 HL092429-03/HL/NHLBI NIH HHS; R01 HL093566/HL/NHLBI NIH HHS; R01HL078921/HL/NHLBI NIH HHS; R01HL092429/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Carrier Proteins; 0/Ligands; 148294-77-3/noggin protein

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