Document Detail

BMI independently predicts younger age at hip and knee replacement.
MedLine Citation:
PMID:  20379147     Owner:  NLM     Status:  MEDLINE    
Obesity has been identified as a risk factor for the development of hip and knee osteoarthritis (OA) and may play a role in exacerbating existing disease. Therefore, we hypothesized that obese patients would present for hip and knee replacement surgery at a younger age than nonobese patients. From our registry, we performed a cross-sectional study of 841 hip and 804 knee replacement patients. Patients were categorized by BMI ≤ 25 kg/m(2), 25.1-29.9 kg/m(2), 30-34.9 kg/m(2), and ≥ 35 kg/m(2). Linear regression modeling was used to examine the relationship between BMI and age at surgery. Hip and knee replacement patients' mean age at surgery was 7.1 and 7.9 years younger, respectively, if their BMI was ≥ 35 kg/m(2) when compared to patients with a BMI ≤ 25 kg/m(2) (P = 0.002). BMI was a significant independent (of gender, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, surgeon, and comorbidity) predictor of age at knee replacement (P < 0.05). WOMAC scores were significantly worse preoperatively in patients with a BMI ≥ 35 kg/m(2) compared to those with a BMI ≤ 25 kg/m(2) (P < 0.05). Our study indicates that obese patients, especially those with a BMI ≥ 35 kg/m(2), presented for and underwent joint replacement surgery at a younger age as compared to nonobese patients.
Rajiv Gandhi; David Wasserstein; Fahad Razak; J Roderick Davey; Nizar N Mahomed
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Publication Detail:
Type:  Journal Article     Date:  2010-04-08
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  18     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-06-07     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2362-6     Citation Subset:  IM    
Division of Orthopaedic Surgery, University Health Network, Toronto, Ontario, Canada.
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MeSH Terms
Age Factors
Aged, 80 and over
Arthroplasty, Replacement, Hip*
Arthroplasty, Replacement, Knee*
Body Mass Index*
Body Weight
Cross-Sectional Studies
Hip / surgery
Knee / surgery
Linear Models
Middle Aged
Models, Statistical
Obesity / complications*
Osteoarthritis, Hip / etiology,  surgery*
Osteoarthritis, Knee / etiology,  surgery*

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