| BM 13.505, a selective thromboxane receptor antagonist, reduces myocardial infarct size following coronary artery reperfusion. | |
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MedLine Citation:
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PMID: 2532749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to assess the effectiveness of the thromboxane receptor antagonist, BM 13.505, in limiting myocardial infarct size in rats subjected to 30 min of coronary artery occlusion followed by reperfusion for 5.5 hr (MI/R). Myocardial infarct size was determined histochemically with triphenyltetrazolium chloride staining of the left ventricle. BM 13.505 (30 mg/kg, i.p.) was administered 1 min prior to coronary artery occlusion. In MI/R-vehicle treated animals, myocardial infarct size was 39 +/- 6% of the left ventricle. In MI/R-BM 13.505 treated animals, reperfusion injury was reduced by 50% to 19 +/- 7% of the left ventricle (p less than 0.05, compared to the MI/R-vehicle group). There were no significant differences in mean arterial blood pressure, heart rate, platelet count or white blood cell count between the treatment groups. Incubation of cultured L929 cells with the thromboxane/endoperoxide mimetic U 46619 produced a cytolytic effect, with an EC50 value of 125 microM. Addition of BM 13.505 at concentrations up to 30 microM did not protect against the cytolytic effect of U 46619, suggesting a non-receptor-mediated mechanism. These data indicate that hemodynamic, hematologic or cytoprotective factors do not explain the cardioprotective effects of BM 13.505. These results provide further evidence that antagonism of thromboxane receptors is beneficial in myocardial ischemia/reperfusion injury. |
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Authors:
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E F Smith; C Q Earl; J W Egan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 38 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-02-22 Completed Date: 1990-02-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 15-23 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Smith Kline and French Laboratories, King of Prussia, PA 19406. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Coronary Circulation Coronary Vessels / drug effects*, metabolism Cytosol / drug effects, metabolism Male Myocardial Infarction / drug therapy* Myocardial Reperfusion* Phenylacetates / pharmacology* Rats Rats, Inbred Strains Receptors, Prostaglandin / drug effects* Receptors, Thromboxane Sulfonamides / pharmacology* Thromboxanes / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Phenylacetates; 0/Receptors, Prostaglandin; 0/Receptors, Thromboxane; 0/Sulfonamides; 0/Thromboxanes; 105218-03-9/daltroban |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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