Document Detail


BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development.
MedLine Citation:
PMID:  17890024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanisation, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacological effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this molecule.
Authors:
Demetrio Raldúa; Patrick J Babin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-22
Journal Detail:
Title:  Toxicology letters     Volume:  175     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-23     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Laboratory of Environmental Toxicology (UPC), CN150, 08220 Terrassa, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / abnormalities,  drug effects
Chelating Agents / toxicity*
Copper / metabolism*,  pharmacology
Cyclopentanes / toxicity*
Embryo, Nonmammalian / abnormalities,  drug effects*
Melanins / metabolism
Notochord / abnormalities,  drug effects
Phenotype
Protective Agents / pharmacology
Scavenger Receptors, Class B / antagonists & inhibitors*,  metabolism
Skin Pigmentation / drug effects
Thiosemicarbazones / toxicity*
Zebrafish / abnormalities*
Chemical
Reg. No./Substance:
0/2-hexyl-1-cyclopentanone thiosemicarbazone; 0/Chelating Agents; 0/Cyclopentanes; 0/Melanins; 0/Protective Agents; 0/Scavenger Receptors, Class B; 0/Thiosemicarbazones; 7440-50-8/Copper; 7447-39-4/cupric chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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