| BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. | |
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MedLine Citation:
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PMID: 17890024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanisation, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacological effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this molecule. |
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Authors:
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Demetrio Raldúa; Patrick J Babin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-22 |
Journal Detail:
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Title: Toxicology letters Volume: 175 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-23 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Laboratory of Environmental Toxicology (UPC), CN150, 08220 Terrassa, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / abnormalities, drug effects Chelating Agents / toxicity* Copper / metabolism*, pharmacology Cyclopentanes / toxicity* Embryo, Nonmammalian / abnormalities, drug effects* Melanins / metabolism Notochord / abnormalities, drug effects Phenotype Protective Agents / pharmacology Scavenger Receptors, Class B / antagonists & inhibitors*, metabolism Skin Pigmentation / drug effects Thiosemicarbazones / toxicity* Zebrafish / abnormalities* |
| Chemical | |
Reg. No./Substance:
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0/2-hexyl-1-cyclopentanone thiosemicarbazone; 0/Chelating Agents; 0/Cyclopentanes; 0/Melanins; 0/Protective Agents; 0/Scavenger Receptors, Class B; 0/Thiosemicarbazones; 7440-50-8/Copper; 7447-39-4/cupric chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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