Document Detail


BIK (Bcl2-Interacting Killer) CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications.
MedLine Citation:
PMID:  22288719     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract BIK (bcl2-interacting killer) is the founding member of the BH3-only BCL-2 family of pro-apoptotic proteins, which is found suppressed in various cancers. In multiple myeloma (MM), BIK has been shown to be epigenetically silenced in vitro but there is lack of clinical data. We investigated CpG methylation status of BIK promoter in a well-characterized clinical series of multiple myeloma (MM) patients and analyzed for clinical relevance. Forty MM patients (21 male, 19 female, mean age 66) were studied. According to International Staging System (ISS) there were classified to stage-I 16 patients, stage-II 12 patients and stage-III 12 patients. Methylation in the BIK CpG island was assessed by methylation-specific PCR (MSP) assay. Logistic regression analysis was used to investigate for associations between gene methylation and age, ISS stage, performance status, extramedullary disease, bone disease, anemia (Hb10<mg/dl), serum albumin, beta 2 microglobulin levels and relapsed/refractory disease. Methylation in the BIK CpG Island was detected in 16 patients (40%) with a trend favouring male gender (OR=3.08, p=0.09) and the development of bone disease and extramedullary disease (OR=1.6, p=0.35 and OR=3, p=0.14 respectively). MM patients with methylated the BIK CpG island had a statistically significant risk for evolving into relapsed/refractory disease (OR=5.4, p=0.03). This study provides clinical evidence that methylation-induced transcriptional silencing of BIK pro-apoptotic gene may occur in MM, which might serve as a predictor of developing relapsed/refractory MM. These findings warrant validation in larger cohorts of patients and suggest therapeutic utility for agents that enhance BIK expression.
Authors:
Eleftheria Hatzimichael; Aggeliki Dasoula; Valentinos Kounnis; Leonidas Benetatos; Aggeliki Dasoula; Cristiana Lo Nigro; Laura Lattanzio; Alexandra Papoudou-Bai; George Dranitsaris; Evangelos Briasoulis; Tim Crook
Related Documents :
11678899 - Lack of age-associated lfa-1 up-regulation and impaired icam-1 binding in lymphocytes f...
6980949 - Depressed t cell proliferative responses in hodgkin's disease: role of monocyte-mediate...
3817609 - Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sep...
3482989 - Hla-a,b and dr antigens in chronic lymphocytic leukaemia.
19737369 - Cytotoxic t lymphocyte-associated antigen-4 polymorphism in patients with rheumatic hea...
2306519 - Detection of non-hodgkin's lymphoma in the peripheral blood by analysis of antigen rece...
16188419 - The incidence of hepatic pseudolesions caused by focal rib compression as seen on multi...
3955239 - Defective erythroid progenitor differentiation system in congenital hypoplastic (diamon...
21161199 - Clinical and angiographic factors related to the prognosis of cavernous sinus dural art...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-30
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pre-operative factors predicting good outcome in terms of health-related quality of life after ACL r...
Next Document:  Body Awareness Rating Questionnaire: Measurement properties.