| BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 20872321 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BI-10773, being developed by Boehringer Ingelheim Corp, is a sodium-glucose cotransporter (SGLT)2 inhibitor for the oral treatment of type 2 diabetes mellitus (T2DM). Preclinical and clinical research has demonstrated that inhibition of SGLT2, the major pathway of renal glucose reabsorption, leads to increased urinary glucose excretion with concomitant reductions in fasting and postprandial plasma glucose levels, HbA1c levels and body mass. In phase I clinical trials in patients with T2DM, once-daily BI-10773 increased urinary glucose excretion resulting in dose-proportional reductions in fasting plasma glucose and mean daily glucose levels. BI-10773 was not associated with significant hypoglycemic episodes or other clinically important adverse events. Because of its mechanism of action, BI-10773 may be combined with other oral antidiabetic agents; indeed, the results of small trials suggested that coadministration of BI-10773 and metformin was safe and well tolerated. In animal studies, BI-10773 correlated with an increase in urinary volume and a reduction in body fat but not water content. This may represent an additional benefit of BI-10773 for the control of T2DM. At the time of publication, phase III clinical trials of BI-10773 were underway. |
| | |
Authors:
|
Inês Aires; Joaquim Calado |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current opinion in investigational drugs (London, England : 2000) Volume: 11 ISSN: 2040-3429 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
|
Languages: eng Pagination: 1182-90 Citation Subset: IM |
Affiliation:
|
New University of Lisbon, Department of Genetics, Lisbon, Portugal. inesaires@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Eliglustat tartrate, an orally active glucocerebroside synthase inhibitor for the potential treatmen...
Next Document: Helicobacter pylori infection in mother and infant pairs in Anatolia.