Document Detail


BE-2 antigen: appearance in activation and long-term growth of T cells.
MedLine Citation:
PMID:  2313117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The BE-2 lymphocyte surface protein is frequently expressed by the malignant cells of cutaneous T-cell lymphoma (CTCL) but is not detectable on the surface of normal resting peripheral blood lymphocytes. The expression of BE-2 by normal T cells can be induced by lectin stimulation. Membrane expression of BE-2 surpasses that of the membrane receptor for IL-2, another T-cell activation marker, at day 5. The peak expression of BE-2 appears at day 6-8. The appearance of BE-2 could also be demonstrated after anti-CD3 and allogeneic stimulation. Long-term T-cell clones derived from normal donors and maintained in culture with periodic stimulation were also found to express BE-2 continuously. Thus, BE-2 is a late activation marker not expressed on normal peripheral blood lymphocytes and pathologically expressed on circulating malignant cells in the disease CTCL.
Authors:
P W Heald; C L Berger; T Yamamura; J McNamara; R L Edelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  94     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-23     Completed Date:  1990-04-23     Revised Date:  2006-06-16    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  452-5     Citation Subset:  IM    
Affiliation:
Yale University School of Medicine, Department of Dermatology, New Haven, Connecticut.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / analysis*
Antigens, Surface / analysis*
Humans
Lymphocyte Activation*
Lymphoma / immunology*
Membrane Glycoproteins*
Skin Neoplasms / immunology*
T-Lymphocytes / immunology
Time Factors
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Surface; 0/CTAGE1 protein, human; 0/Membrane Glycoproteins

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