| BE-2 antigen: appearance in activation and long-term growth of T cells. | |
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MedLine Citation:
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PMID: 2313117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The BE-2 lymphocyte surface protein is frequently expressed by the malignant cells of cutaneous T-cell lymphoma (CTCL) but is not detectable on the surface of normal resting peripheral blood lymphocytes. The expression of BE-2 by normal T cells can be induced by lectin stimulation. Membrane expression of BE-2 surpasses that of the membrane receptor for IL-2, another T-cell activation marker, at day 5. The peak expression of BE-2 appears at day 6-8. The appearance of BE-2 could also be demonstrated after anti-CD3 and allogeneic stimulation. Long-term T-cell clones derived from normal donors and maintained in culture with periodic stimulation were also found to express BE-2 continuously. Thus, BE-2 is a late activation marker not expressed on normal peripheral blood lymphocytes and pathologically expressed on circulating malignant cells in the disease CTCL. |
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Authors:
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P W Heald; C L Berger; T Yamamura; J McNamara; R L Edelson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 94 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-04-23 Completed Date: 1990-04-23 Revised Date: 2006-06-16 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 452-5 Citation Subset: IM |
Affiliation:
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Yale University School of Medicine, Department of Dermatology, New Haven, Connecticut. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm
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analysis* Antigens, Surface / analysis* Humans Lymphocyte Activation* Lymphoma / immunology* Membrane Glycoproteins* Skin Neoplasms / immunology* T-Lymphocytes / immunology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Antigens, Surface; 0/CTAGE1 protein, human; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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