Document Detail

BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity.
MedLine Citation:
PMID:  19937367     Owner:  NLM     Status:  MEDLINE    
The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves. Furthermore, this upregulation may correlate with mitotic activity. Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing. Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown. An impaired growth regulation and imbalance between mitosis and apoptosis can be assumed. However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors have to be identified. Neurotrophic factors are involved in regulation of developmental processes in neuronal tissues and regeneration after peripheral nerve trauma and also reveal mitogenic effects on glial cell populations. Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR. The expression data were correlated to the proliferation-associated Ki-67 labelling index. A significant higher BDNF expression was observed in the vestibular schwannoma, whereas gene expression of artemin and GDNF was upregulated in peripheral nerves. The correlation between LI and BDNF, TGF-beta1 and Ret was found to be significant in the vestibular schwannoma. Our results demonstrate a coherence between BDNF expression and proliferative activity in the vestibular schwannoma. Based on these results, we propose a pivotal role for BDNF in modulating the vestibular schwannoma growth.
Frauke Kramer; Timo Stöver; Athanasia Warnecke; Marc Diensthuber; Thomas Lenarz; Kirsten Wissel
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-11-25
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  98     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.
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MeSH Terms
Brain-Derived Neurotrophic Factor / genetics*,  metabolism
Cell Proliferation*
Gene Expression Regulation, Neoplastic / physiology*
Glial Cell Line-Derived Neurotrophic Factor / genetics,  metabolism
Ki-67 Antigen / metabolism
Middle Aged
Nerve Tissue Proteins / genetics,  metabolism
Neuroma, Acoustic / genetics*,  pathology
Peripheral Nerves / metabolism
RNA, Messenger / metabolism*
Statistics as Topic / methods
Statistics, Nonparametric
Transforming Growth Factor beta1 / genetics,  metabolism
Transforming Growth Factor beta2 / genetics,  metabolism
Up-Regulation / physiology*
Young Adult
Reg. No./Substance:
0/ARTN protein, human; 0/Brain-Derived Neurotrophic Factor; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Ki-67 Antigen; 0/Nerve Tissue Proteins; 0/RNA, Messenger; 0/Transforming Growth Factor beta1; 0/Transforming Growth Factor beta2

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