| BDNF increases BrdU-IR cells in the injured adult zebra finch hippocampus. | |
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MedLine Citation:
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PMID: 19512953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Steroid-mediated cell proliferation, differentiation, and survival can be triggered by learning, experience, and brain injury. In the uninjured canary song system, testosterone induces cell proliferation that is blocked by an antibody to brain-derived neurotrophic factor (BDNF). However, little is known with regard to the effects of neurotrophic factors on injury-induced cell proliferation and incorporation. To address this, adult male zebra finches received bilateral hippocampal lesions by infusing saline into one hemisphere and BDNF into the other. BrdU (2-bromo-5-deoxyuridine) was then injected to label mitotic cells. A greater number of BrdU-immunoreactive (BrdU-IR) cells were observed in the BDNF-treated hemisphere in the hippocampus, but not in the septum or stem cell-rich subventricular zone, indicating that BDNF promoted localized cell proliferation and incorporation at the injury site only. |
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Authors:
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Nikola N Lucas; Diane W Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Neuroreport Volume: 20 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1066-70 Citation Subset: IM |
Affiliation:
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Department of Psychology, California State University, Long Beach, California 90840, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Brain / physiopathology Brain Injuries / physiopathology* Brain-Derived Neurotrophic Factor / metabolism*, pharmacology Bromodeoxyuridine Cell Count Cell Proliferation* Cell Survival / physiology Finches Hippocampus / physiopathology* Immunohistochemistry Male Mitosis / physiology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MH59730/MH/NIMH NIH HHS; S06GM063119/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 59-14-3/Bromodeoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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