Document Detail

BDNF and the central control of feeding: accidental bystander or essential player?
MedLine Citation:
PMID:  23333344     Owner:  NLM     Status:  MEDLINE    
A considerable body of evidence links diminished brain-derived neurotrophic factor (BDNF) signaling to energy balance dysregulation and severe obesity in humans and rodents. Because BDNF exhibits broad neurotrophic properties, the underpinnings of these effects and its true role in the central regulation of food intake remain topics of debate in the field. Here, I discuss recent evidence supporting a critical role for this neurotrophin in physiological mechanisms regulating nutrient intake and body weight in the mature brain. They include reports of functional interactions of BDNF with central anorexigenic and orexigenic signaling pathways and evidence of recognized appetite hormones exerting neurotrophic effects similar to those of BDNF.
Maribel Rios
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-18
Journal Detail:
Title:  Trends in neurosciences     Volume:  36     ISSN:  1878-108X     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-31     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Brain / physiology*
Brain-Derived Neurotrophic Factor / physiology*
Eating / physiology*
Feeding Behavior / physiology*
Grant Support
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

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