Document Detail

BDNF Val66Met polymorphism and brain volumes in multiple sclerosis.
MedLine Citation:
PMID:  20953813     Owner:  NLM     Status:  In-Data-Review    
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy.
D Dinacci; A Tessitore; A Russo; M L De Bonis; L Lavorgna; O Picconi; R Sacco; S Bonavita; A Gallo; G Servillo; L Marcuccio; M Comerci; P Galletti; B Alfano; G Tedeschi
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Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  32     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy,
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