| BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory. | |
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MedLine Citation:
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PMID: 20601027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical exercise induces widespread neurobiological adaptations and improves learning and memory. Most research in this field has focused on hippocampus-based spatial tasks and changes in brain-derived neurotrophic factor (BDNF) as a putative substrate underlying exercise-induced cognitive improvements. Chronic exercise can also be anxiolytic and causes adaptive changes in stress-reactivity. The present study employed a perirhinal cortex-dependent object recognition task as well as the elevated plus maze to directly test for interactions between the cognitive and anxiolytic effects of exercise in male Long Evans rats. Hippocampal and perirhinal cortex tissue was collected to determine whether the relationship between BDNF and cognitive performance extends to this non-spatial and non-hippocampal-dependent task. We also examined whether the cognitive improvements persisted once the exercise regimen was terminated. Our data indicate that 4weeks of voluntary exercise every-other-day improved object recognition memory. Importantly, BDNF expression in the perirhinal cortex of exercising rats was strongly correlated with object recognition memory. Exercise also decreased anxiety-like behavior, however there was no evidence to support a relationship between anxiety-like behavior and performance on the novel object recognition task. There was a trend for a negative relationship between anxiety-like behavior and hippocampal BDNF. Neither the cognitive improvements nor the relationship between cognitive function and perirhinal BDNF levels persisted after 2weeks of inactivity. These are the first data demonstrating that region-specific changes in BDNF protein levels are correlated with exercise-induced improvements in non-spatial memory, mediated by structures outside the hippocampus and are consistent with the theory that, with regard to object recognition, the anxiolytic and cognitive effects of exercise may be mediated through separable mechanisms. |
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Authors:
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Michael E Hopkins; David J Bucci |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-30 |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 94 ISSN: 1095-9564 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-13 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: United States |
Other Details:
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Languages: eng Pagination: 278-84 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anxiety / metabolism Brain-Derived Neurotrophic Factor / metabolism* Cerebral Cortex / metabolism* Discrimination Learning / physiology* Male Maze Learning / physiology Physical Conditioning, Animal / physiology* Rats Rats, Long-Evans Recognition (Psychology) / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH082893/MH/NIMH NIH HHS; R01 MH082893-02/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor |
| Comments/Corrections | |
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