| BD focalpoint slide profiler performance with atypical glandular cells on SurePath Papanicolaou smears. | |
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MedLine Citation:
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PMID: 20209621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The FocalPoint Slide Profiler is an automated cervical cytology screening system that is approved for primary screening. It identifies up to 25% of slides as requiring No Further Review. However, few studies have evaluated FocalPoint performance with glandular abnormalities. METHODS: Sixty-six SurePath Papanicolaou (Pap) tests with a diagnosis of atypical glandular cells were identified. A total of 172 Pap tests with a diagnosis of "endometrial cells present" were included as controls. Follow-up histology was abnormal if diagnosed as high-grade squamous intraepithelial lesions, adenocarcinoma in situ, carcinoma, or complex endometrial hyperplasia. The FocalPoint software ranked each case into 1 of 7 categories: quintiles 1 (high risk) through 5 (low risk), No Further Review, and Process Review. RESULTS: A total of 215 slides were qualified for review; 38 (57.6%) atypical glandular cells cases were abnormal on follow-up biopsy, and 27 (71.1%) atypical glandular cells with abnormal follow-up qualified for review; no cases were classified No Further Review, and 9 (33%) were ranked in quintile 1. Twenty-three (82.1%) atypical glandular cells with benign follow-up were qualified for review; 3 (11%) cases were classified No Further Review, and 4 (17%) were ranked in quintile 1. There was a statistically significant difference between the ranking of benign atypical glandular cells cases, abnormal atypical glandular cells cases, and control cases (P = .03). However, when collapsed into No Further Review versus all other quintiles, the differences were not significant (P = .20). CONCLUSIONS: The FocalPoint Slide Profiler did not classify glandular lesions with abnormal follow-up in the No Further Review category. However, these cases were not preferentially ranked in quintile 1. FocalPoint-screened slides need to be carefully reviewed for glandular abnormalities, regardless of the quintile ranking. |
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Authors:
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Deborah J Chute; Harumi Lim; Christina S Kong |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer cytopathology Volume: 118 ISSN: 1934-662X ISO Abbreviation: Cancer Cytopathol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101499453 Medline TA: Cancer Cytopathol Country: United States |
Other Details:
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Languages: eng Pagination: 68-74 Citation Subset: IM |
Copyright Information:
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(c) 2010 American Cancer Society. |
Affiliation:
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Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA. dchute1@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology* Adult Aged Aged, 80 and over Cervical Intraepithelial Neoplasia / pathology Early Detection of Cancer Female Humans Image Processing, Computer-Assisted* Middle Aged Uterine Cervical Dysplasia / pathology* Uterine Cervical Neoplasms / pathology* Vaginal Smears* |
| Comments/Corrections | |
Comment In:
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Cancer Cytopathol. 2010 Apr 25;118(2):65-7
[PMID:
20336779
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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