Document Detail

BD focalpoint slide profiler performance with atypical glandular cells on SurePath Papanicolaou smears.
MedLine Citation:
PMID:  20209621     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The FocalPoint Slide Profiler is an automated cervical cytology screening system that is approved for primary screening. It identifies up to 25% of slides as requiring No Further Review. However, few studies have evaluated FocalPoint performance with glandular abnormalities. METHODS: Sixty-six SurePath Papanicolaou (Pap) tests with a diagnosis of atypical glandular cells were identified. A total of 172 Pap tests with a diagnosis of "endometrial cells present" were included as controls. Follow-up histology was abnormal if diagnosed as high-grade squamous intraepithelial lesions, adenocarcinoma in situ, carcinoma, or complex endometrial hyperplasia. The FocalPoint software ranked each case into 1 of 7 categories: quintiles 1 (high risk) through 5 (low risk), No Further Review, and Process Review. RESULTS: A total of 215 slides were qualified for review; 38 (57.6%) atypical glandular cells cases were abnormal on follow-up biopsy, and 27 (71.1%) atypical glandular cells with abnormal follow-up qualified for review; no cases were classified No Further Review, and 9 (33%) were ranked in quintile 1. Twenty-three (82.1%) atypical glandular cells with benign follow-up were qualified for review; 3 (11%) cases were classified No Further Review, and 4 (17%) were ranked in quintile 1. There was a statistically significant difference between the ranking of benign atypical glandular cells cases, abnormal atypical glandular cells cases, and control cases (P = .03). However, when collapsed into No Further Review versus all other quintiles, the differences were not significant (P = .20). CONCLUSIONS: The FocalPoint Slide Profiler did not classify glandular lesions with abnormal follow-up in the No Further Review category. However, these cases were not preferentially ranked in quintile 1. FocalPoint-screened slides need to be carefully reviewed for glandular abnormalities, regardless of the quintile ranking.
Deborah J Chute; Harumi Lim; Christina S Kong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer cytopathology     Volume:  118     ISSN:  1934-662X     ISO Abbreviation:  Cancer Cytopathol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101499453     Medline TA:  Cancer Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Copyright Information:
(c) 2010 American Cancer Society.
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
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MeSH Terms
Adenocarcinoma / pathology*
Aged, 80 and over
Cervical Intraepithelial Neoplasia / pathology
Early Detection of Cancer
Image Processing, Computer-Assisted*
Middle Aged
Uterine Cervical Dysplasia / pathology*
Uterine Cervical Neoplasms / pathology*
Vaginal Smears*
Comment In:
Cancer Cytopathol. 2010 Apr 25;118(2):65-7   [PMID:  20336779 ]

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