Document Detail


BCL2A1: the underdog in the BCL2 family.
MedLine Citation:
PMID:  22075983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic pathway. They comprise both pro- and anti-apoptotic proteins, which interact in various ways to induce or prevent pore formation in the outer mitochondrial membrane. Due to their central function in the apoptotic machinery, BCL2 proteins are often deregulated in cancer. To this end, many anti-apoptotic BCL2 proteins have been identified as important cellular oncogenes and attractive targets for anti-cancer therapy. In this review, the existing knowledge on B-cell lymphoma 2-related protein A1 (BCL2A1)/Bcl-2-related gene expressed in fetal liver (Bfl-1), one of the less extensively studied anti-apoptotic BCL2 proteins, is summarized. BCL2A1 is a highly regulated nuclear factor κB (NF-κB) target gene that exerts important pro-survival functions. In a physiological context, BCL2A1 is mainly expressed in the hematopoietic system, where it facilitates survival of selected leukocytes subsets and inflammation. However, BCL2A1 is overexpressed in a variety of cancer cells, including hematological malignancies and solid tumors, and may contribute to tumor progression. Therefore, the development of small molecule inhibitors of BCL2A1 may be a promising approach mainly to sensitize tumor cells for apoptosis and thus improve the efficiency of anti-cancer therapy.
Authors:
M Vogler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-11
Journal Detail:
Title:  Cell death and differentiation     Volume:  19     ISSN:  1476-5403     ISO Abbreviation:  Cell Death Differ.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-03-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9437445     Medline TA:  Cell Death Differ     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Affiliation:
MRC Toxicology Unit, University of Leicester, Leicester, UK. mv62@le.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antineoplastic Agents / chemistry,  therapeutic use
Apoptosis*
Apoptosis Regulatory Proteins / genetics,  metabolism*
Gene Expression Regulation
Humans
Mice
Molecular Sequence Data
NF-kappa B / metabolism
Neoplasms / drug therapy,  metabolism*
Protein Binding
Protein Conformation
Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors,  genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
//Medical Research Council
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Apoptosis Regulatory Proteins; 0/BCL2-related protein A1; 0/NF-kappa B; 0/Proto-Oncogene Proteins c-bcl-2
Comments/Corrections

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