Document Detail

BCL-2: pro-or anti-oxidant?
MedLine Citation:
PMID:  19482643     Owner:  NLM     Status:  MEDLINE    
Bcl-2 is recognized as an oncoprotein via its ability to impede death signaling by sequestrating pro-apoptotic proteins such as Bax and Bak as well as preserving mitochondrial outer membrane integrity. Recently, a growing body of evidence has evaluated the role of Bcl-2 in intracellular redox regulation and its downstream effects on life and death decisions in cancer cells. On the backdrop of these findings, we discuss here the classical anti-apoptotic role of Bcl-2 in malignant cells, and review the significance of Bcl-2-mediated regulation of tumor redox status. We discuss recent evidence that underscores a paradigm shift in the way cellular redox status impacts cell fate decisions via the effect of Bcl-2 on mitochondrial physiology. The ability of Bcl-2 to promote, modulate and optimize mitochondrial respiration under different redox states highlights the importance of mitochondrial bioenergetics, ROS and the roles they might play in the onset and/or maintenance of oncogenesis.
Zhi Xiong Chen; Shazib Pervaiz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  1     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-01     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  IM    
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
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MeSH Terms
Apoptosis / physiology*
Mitochondria / physiology*
Models, Biological*
Neoplasms / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Reactive Oxygen Species / metabolism*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; 0/Reactive Oxygen Species

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