| BCL-2: pro-or anti-oxidant? | |
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MedLine Citation:
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PMID: 19482643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bcl-2 is recognized as an oncoprotein via its ability to impede death signaling by sequestrating pro-apoptotic proteins such as Bax and Bak as well as preserving mitochondrial outer membrane integrity. Recently, a growing body of evidence has evaluated the role of Bcl-2 in intracellular redox regulation and its downstream effects on life and death decisions in cancer cells. On the backdrop of these findings, we discuss here the classical anti-apoptotic role of Bcl-2 in malignant cells, and review the significance of Bcl-2-mediated regulation of tumor redox status. We discuss recent evidence that underscores a paradigm shift in the way cellular redox status impacts cell fate decisions via the effect of Bcl-2 on mitochondrial physiology. The ability of Bcl-2 to promote, modulate and optimize mitochondrial respiration under different redox states highlights the importance of mitochondrial bioenergetics, ROS and the roles they might play in the onset and/or maintenance of oncogenesis. |
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Authors:
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Zhi Xiong Chen; Shazib Pervaiz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 1 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2010-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 263-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. phssp@nus.edu.sg |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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physiology* Humans Mitochondria / physiology* Models, Biological* Neoplasms / metabolism* Oxidation-Reduction Proto-Oncogene Proteins c-bcl-2 / metabolism* Reactive Oxygen Species / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 0/Reactive Oxygen Species |
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