| BCL-2 in prostate cancer: a minireview. | |
| | |
MedLine Citation:
|
PMID: 12510149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prostate cancer progression and the development of androgen-independent prostate cancer have been largely related to a number of genetic abnormality that affect not only the androgen receptor but also crucial molecules involved in the regulation of survival or apoptotic pathways. One of these molecules, the pro-survival protein BCL-2, has been associated with the development of androgen-independent prostate cancer due to its high levels of expression in androgen-independent tumors in advanced stages of the pathology. The upregulation of BCL-2 after androgen ablation in prostate carcinoma cell lines and in a castrated-male rat model further established a connection between BCL-2 expression and prostate cancer progression. This review focuses on the experimental evidence that associates BCL-2 expression with prostate carcinogenesis and cancer progression, and analyzes the evidence that links the phosphatidylinositol 3-kinase (PI 3-kinase)/nuclear factor kappa B (NF-kappaB) survival pathway with the upregulation of BCL-2. The way in which hormone ablation influences this survival pathway and the potential application of novel therapeutic strategies to overcome this anti-apoptotic mechanism is examined. |
| | |
Authors:
|
S D Catz; J L Johnson |
Related Documents
:
|
10597729 - Chemotherapy of advanced prostatic carcinoma. 12580559 - Endocrine causes of impotence (nondiabetes). 1423159 - The management of a case of treatment-resistant paraphilia with a long-acting lhrh agon... 19795609 - The selection of hormonal therapy in prostate cancer: who, when, and for how long? 10087729 - Hormonal ablation therapy for metastatic prostatic carcinoma: a review. 7588959 - Rapid occurrence of thelarche and menarche induced by hydrocortisone in a teenage girl ... 20526349 - Rearrangements of the raf kinase pathway in prostate cancer, gastric cancer and melanoma. 22970209 - Plasma mir-601 and mir-760 are novel biomarkers for the early detection of colorectal c... 16214989 - Nutritional therapy for cancer-induced weight loss. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Apoptosis : an international journal on programmed cell death Volume: 8 ISSN: 1360-8185 ISO Abbreviation: Apoptosis Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2003-01-02 Completed Date: 2003-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
|
Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
|
Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. scatz@scripps.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Phosphatidylinositol 3-Kinase
/
metabolism Androgens / metabolism Animals Apoptosis Cell Survival Disease Models, Animal Disease Progression Humans Male NF-kappa B / metabolism Prostatic Neoplasms / metabolism*, therapy Proto-Oncogene Proteins c-bcl-2 / metabolism, physiology* Rats Receptors, Androgen / metabolism Signal Transduction Tumor Necrosis Factor-alpha / metabolism Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
|
AI24227/AI/NIAID NIH HHS; AI28479/AI/NIAID NIH HHS; AI44434/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Androgens; 0/NF-kappa B; 0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Androgen; 0/Tumor Necrosis Factor-alpha; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of cell apoptosis by protein kinase c delta.
Next Document: CSE1L/CAS: its role in proliferation and apoptosis.