Document Detail


BCL-2 in prostate cancer: a minireview.
MedLine Citation:
PMID:  12510149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostate cancer progression and the development of androgen-independent prostate cancer have been largely related to a number of genetic abnormality that affect not only the androgen receptor but also crucial molecules involved in the regulation of survival or apoptotic pathways. One of these molecules, the pro-survival protein BCL-2, has been associated with the development of androgen-independent prostate cancer due to its high levels of expression in androgen-independent tumors in advanced stages of the pathology. The upregulation of BCL-2 after androgen ablation in prostate carcinoma cell lines and in a castrated-male rat model further established a connection between BCL-2 expression and prostate cancer progression. This review focuses on the experimental evidence that associates BCL-2 expression with prostate carcinogenesis and cancer progression, and analyzes the evidence that links the phosphatidylinositol 3-kinase (PI 3-kinase)/nuclear factor kappa B (NF-kappaB) survival pathway with the upregulation of BCL-2. The way in which hormone ablation influences this survival pathway and the potential application of novel therapeutic strategies to overcome this anti-apoptotic mechanism is examined.
Authors:
S D Catz; J L Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  8     ISSN:  1360-8185     ISO Abbreviation:  Apoptosis     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-02     Completed Date:  2003-07-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM    
Affiliation:
Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. scatz@scripps.edu
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / metabolism
Androgens / metabolism
Animals
Apoptosis
Cell Survival
Disease Models, Animal
Disease Progression
Humans
Male
NF-kappa B / metabolism
Prostatic Neoplasms / metabolism*,  therapy
Proto-Oncogene Proteins c-bcl-2 / metabolism,  physiology*
Rats
Receptors, Androgen / metabolism
Signal Transduction
Tumor Necrosis Factor-alpha / metabolism
Up-Regulation
Grant Support
ID/Acronym/Agency:
AI24227/AI/NIAID NIH HHS; AI28479/AI/NIAID NIH HHS; AI44434/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 0/NF-kappa B; 0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Androgen; 0/Tumor Necrosis Factor-alpha; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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