Document Detail


BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells.
MedLine Citation:
PMID:  11949826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radiotherapy is the standard treatment for glioblastoma. Here, we assessed the radiosensitivity of 12 human malignant glioma cell lines in vitro and correlated these data with irradiation-induced cell cycle changes, chemosensitivity profiles and BCL-2 family protein expression. Irradiation at 3 Gy failed to cause major cell cycle perturbations. Radioresistance was associated with collateral sensitivity to the topoisomerase II inhibitors, teniposide and doxorubicin. High levels of BCL-XL and low levels of BAX were independently linked to radioresistance. Ectopic expression of a BAX transgene induced radiosensitization in the LN-18 cell line. Thus, BCL-2 family protein expression modulates radiosensitivity in human glioma cells and targeted alterations in BCL-2 family protein expression are a promising strategy to improve the therapeutic efficacy of radiotherapy for gliomas.
Authors:
Johannes R Streffer; Andreas Rimner; Johannes Rieger; Ulrike Naumann; Hans-Peter Rodemann; Michael Weller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  56     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Tübingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology
Brain Neoplasms*
Cell Cycle / drug effects,  radiation effects
Dose-Response Relationship, Radiation
Gene Expression Regulation, Neoplastic / radiation effects*
Gene Transfer Techniques
Glioma*
Humans
Proto-Oncogene Proteins / analysis,  genetics
Proto-Oncogene Proteins c-bcl-2 / analysis*,  genetics*
Tumor Cells, Cultured / chemistry,  cytology,  radiation effects
bcl-2-Associated X Protein
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/BAX protein, human; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein

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