| The BBB Study: the effect of intensified antihypertensive treatment on the level of blood pressure, side-effects, morbidity and mortality in "well-treated" hypertensive patients. Behandla Blodtryck Bättre. | |
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MedLine Citation:
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PMID: 7994450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The BBB study (Swedish for Behandla Blodtryck Bättre or Treat Blood Pressure Better) was a multicenter trial designed to investigate three aspects of antihypertensive treatment: i) Is it possible to lower the diastolic blood pressure further in "well-treated" hypertensive patients through intensified therapy? ii) Can this aim be fulfilled without increasing the incidence or severity of side-effects? iii) If i) and ii) can be answered in the affirmative, will the further reduction in diastolic blood pressure be associated with a further reduction in hypertension-associated mortality and morbidity? Altogether 2127 hypertensive men and women with an average age of 59.8 years (46-71) were recruited at 142 primary health care centers in Sweden. Approximately 10,000 patient-years were accumulated. All patients had treated essential hypertension and all had diastolic blood pressures in the range 90-100 mmHg on three consecutive visits before entering the study. The patients were randomized to either intensified treatment aiming at a blood pressure < or = 80 mmHg diastolic (group A) or to unchanged therapy (group B). A difference between group A and group B in diastolic blood pressure of 7-7.5 mmHg was achieved for > 4 years. Adverse effects were studied in detail in 100 randomly selected patients from each group using a special questionnaire and a visual analogue scale. The adverse effect score fell significantly in group A but remained unchanged in group B. Regarding cardiovascular morbidity and mortality there were no significant differences between groups A and B, the total number of strokes and myocardial infarcts being 28 in group A and 29 in group B.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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L Hannson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure Volume: 3 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1995-01-13 Completed Date: 1995-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
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Languages: eng Pagination: 248-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / adverse effects, therapeutic use* Blood Pressure / drug effects Female Heart Rate / drug effects Humans Hypertension / drug therapy*, mortality, physiopathology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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