| BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat. | |
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MedLine Citation:
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PMID: 1908386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiulcer activity of BAY P 14551 a thiazolylaminobenzimidazole derivative, was evaluated in different experimental ulcer models and its antiulcer activity was compared to that of different reference drugs. The overall activity of the compound was equal to or more potent than that of reference antiulcer drugs, such as pirenzepine, cimetidine and carbenoxolone, but it was not as potent as rioprostil. The ED50 values (expressed as mumol/kg p.o.) were 68 (confidence limits: 51-91) for indomethacin-induced ulcers, 21 (confidence limits: 13-31) for stress-induced ulcers and 1260 mumol/kg p.o. (confidence limits: 412-3800) for ulcers induced by absolute ethanol. The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats. Since inhibition of gastric acid secretion was seen, if at all, only with the higher doses, the gastro-protective action of BAY P 1455 seemed not to be due to an antisecretory effect, but more likely to a gastroprotective action as hypothesised for prostaglandins. |
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Authors:
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A Grassi; J Ippen; M Bruno; G Thomas |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 195 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-09-20 Completed Date: 1991-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 251-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Bayer Italia, Garbagnate M.se MI. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Anti-Ulcer Agents* Benzimidazoles / pharmacology* Cimetidine / pharmacology Corticosterone / blood Cysteamine Duodenal Ulcer / chemically induced, prevention & control Ethanol Female Gastric Acid / secretion Immersion Indomethacin Male Pirenzepine / pharmacology Prostaglandins E / pharmacology Pylorus / surgery Rats Rats, Inbred Strains Rioprostil Stomach Ulcer / etiology, prevention & control Stress, Psychological / complications Thiazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Prostaglandins E; 0/Thiazoles; 131185-01-8/2-(2'-benzimidazolyl)amino-4-methylthiazole; 28797-61-7/Pirenzepine; 50-22-6/Corticosterone; 51481-61-9/Cimetidine; 53-86-1/Indomethacin; 60-23-1/Cysteamine; 64-17-5/Ethanol; 77287-05-9/Rioprostil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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