Document Detail


BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
MedLine Citation:
PMID:  1908386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiulcer activity of BAY P 14551 a thiazolylaminobenzimidazole derivative, was evaluated in different experimental ulcer models and its antiulcer activity was compared to that of different reference drugs. The overall activity of the compound was equal to or more potent than that of reference antiulcer drugs, such as pirenzepine, cimetidine and carbenoxolone, but it was not as potent as rioprostil. The ED50 values (expressed as mumol/kg p.o.) were 68 (confidence limits: 51-91) for indomethacin-induced ulcers, 21 (confidence limits: 13-31) for stress-induced ulcers and 1260 mumol/kg p.o. (confidence limits: 412-3800) for ulcers induced by absolute ethanol. The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats. Since inhibition of gastric acid secretion was seen, if at all, only with the higher doses, the gastro-protective action of BAY P 1455 seemed not to be due to an antisecretory effect, but more likely to a gastroprotective action as hypothesised for prostaglandins.
Authors:
A Grassi; J Ippen; M Bruno; G Thomas
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  195     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Bayer Italia, Garbagnate M.se MI.
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Animals
Anti-Ulcer Agents*
Benzimidazoles / pharmacology*
Cimetidine / pharmacology
Corticosterone / blood
Cysteamine
Duodenal Ulcer / chemically induced,  prevention & control
Ethanol
Female
Gastric Acid / secretion
Immersion
Indomethacin
Male
Pirenzepine / pharmacology
Prostaglandins E / pharmacology
Pylorus / surgery
Rats
Rats, Inbred Strains
Rioprostil
Stomach Ulcer / etiology,  prevention & control
Stress, Psychological / complications
Thiazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Prostaglandins E; 0/Thiazoles; 131185-01-8/2-(2'-benzimidazolyl)amino-4-methylthiazole; 28797-61-7/Pirenzepine; 50-22-6/Corticosterone; 51481-61-9/Cimetidine; 53-86-1/Indomethacin; 60-23-1/Cysteamine; 64-17-5/Ethanol; 77287-05-9/Rioprostil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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