Document Detail

BALF nitrite as an indicator of inflammation in children with cystic fibrosis.
MedLine Citation:
PMID:  15627874     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A unique substance reflecting the degree of inflammation localized to the lower respiratory tract in patients with cystic fibrosis (CF) has been the concern of several investigators and nitric oxide has gained interest for this purpose in the last decades. OBJECTIVES: The aim of this study was to evaluate the cytokine and nitrite levels by showing the relationship between them in serum and bronchoalveolar lavage fluid (BALF) of patients with CF and patients in which flexible fiberoptic bronchoscopy (FFB) was applied because of indications other than infection. METHODS: 20 children with CF with mean age 8.2 years and 10 children as control group with mean age 4.2 years were included in the study. Cultures for aerobes, anaerobes, fungi and mycobacteria, cell differentials, cytokine and nitrite measurements were made from BALF specimens. White blood cell (WBC) count, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (QCRP), cytokine and nitrite levels were measured from serum samples. RESULTS: BALF neutrophil, TNF-alpha, IL-8 and nitrite levels were significantly higher in patients with CF than control patients. There was no correlation between serum and BALF cytokine and nitrite levels. However, there was a significantly positive correlation between BALF IL-8 and nitrite levels in patients with CF (r = 0.5) and also in control patients (r = 0.6). CONCLUSIONS: The results suggest that BALF nitrite levels reflect the degree of inflammation localized to lower respiratory tract and may be a useful indicator of airway inflammation for patients with CF.
Ilker Cetin; Uğur Ozçelik; Ayhan Goçmen; Nural Kiper; Deniz Doğru; Ebru Yalçin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  71     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2005-01-03     Completed Date:  2005-03-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  IM    
Department of Pediatric Chest Diseases, Ihsan Doğramaci Children's Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Blood Sedimentation
Bronchoalveolar Lavage Fluid / chemistry*
Cystic Fibrosis / diagnosis*
Cytokines / analysis*,  blood
Interleukin-8 / analysis,  blood
Leukocyte Count
Nitrites / analysis*,  blood
Reg. No./Substance:
0/Cytokines; 0/Interleukin-8; 0/Nitrites

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